Table 1. Regulation of ferH mRNA... | American Society of Hematology

Table 1.

Regulation of ferH mRNA Translation

Erythroid Progenitor	Self- Renewal	mRNA Distribution (high Tf)	Tf-Dependent Ferritin Production	Tf-Dependent IRP- Modulation
c-Kit	Transient	Polysome-free	No	No

c-Kit/*v-ErbA*	Long-term	Polysome-free + bound	Yes	Yes
c-Kitv-ErbA/EpoR	Long-term	Polysome-free + bound	Yes	Yes
c-Kit/*c-ErbA*	Long-term	Polysome-free	No	No
c-Kit/*v-ErbB*	Long-term	Polysome-free	No	No
c-Kit/*c-ErbB*	Long-term	Polysome-free	No	No
c-Kit *v-ErbA/v-ErbB^	Long-term	Polysome-free + bound	Yes	Yes

c-Kitv-ErbA/v-ErbB^†	Permanent	Polysome-free + bound	Yes	Yes
c-Kit/*v-ErbAv-ErbB/EpoR*^‡	Permanent	Polysome-free + bound	Yes	Yes

Erythroid Progenitor	Self- Renewal	mRNA Distribution (high Tf)	Tf-Dependent Ferritin Production	Tf-Dependent IRP- Modulation
c-Kit	Transient	Polysome-free	No	No

c-Kit/*v-ErbA*	Long-term	Polysome-free + bound	Yes	Yes
c-Kitv-ErbA/EpoR	Long-term	Polysome-free + bound	Yes	Yes
c-Kit/*c-ErbA*	Long-term	Polysome-free	No	No
c-Kit/*v-ErbB*	Long-term	Polysome-free	No	No
c-Kit/*c-ErbB*	Long-term	Polysome-free	No	No
c-Kit *v-ErbA/v-ErbB^	Long-term	Polysome-free + bound	Yes	Yes

c-Kitv-ErbA/v-ErbB^†	Permanent	Polysome-free + bound	Yes	Yes
c-Kit/*v-ErbAv-ErbB/EpoR*^‡	Permanent	Polysome-free + bound	Yes	Yes

Bold italics indicate retroviral overexpression.

Primary clone ts34A6.

Established erythroblast cell line HD3E11.

Established erythroblast cell line HD3E22.