Disaccharide composition of unmodified and desulfated heparins
| Sulfated Disaccharide . | Positions of Sulfation on Disaccharides . | Percent of Total Disaccharides . | |
|---|---|---|---|
| O-sulfated Heparin . | Unmodified Heparin . | ||
| UA-GlcNAc- | None | 6.8 | 3.8 |
| -UA-GlcNSO3- | N | 1.1 | 2.2 |
| -UA-GlcNAc(6-OSO3)- | 6 | 10.8 | 3.1 |
| -UA(2-OSO3)-GlcNAc- | 2 | 12.4 | 1.9 |
| -UA(2-OSO3)-GlcNSO3- | 2, N | 0.8 | 9.1 |
| -UA(2-OSO3)-GlcNAc(6-OSO3)- | 2, 6 | 67.3 | 8.1 |
| -UA(2-OSO3)-GlcNSO3(6-OSO3)-† | 2, N, 6 | 0.8 | 71.7 |
| Sulfated Disaccharide . | Positions of Sulfation on Disaccharides . | Percent of Total Disaccharides . | |
|---|---|---|---|
| O-sulfated Heparin . | Unmodified Heparin . | ||
| UA-GlcNAc- | None | 6.8 | 3.8 |
| -UA-GlcNSO3- | N | 1.1 | 2.2 |
| -UA-GlcNAc(6-OSO3)- | 6 | 10.8 | 3.1 |
| -UA(2-OSO3)-GlcNAc- | 2 | 12.4 | 1.9 |
| -UA(2-OSO3)-GlcNSO3- | 2, N | 0.8 | 9.1 |
| -UA(2-OSO3)-GlcNAc(6-OSO3)- | 2, 6 | 67.3 | 8.1 |
| -UA(2-OSO3)-GlcNSO3(6-OSO3)-† | 2, N, 6 | 0.8 | 71.7 |
Derived from data from Seikagaku America, Inc (personal communication).
Highly (“default”) sulfated disaccharide; UA indicates hexuronic acid (iduronic acid or glucuronic acid); GlcN, glucosamine.