Recurrent Chromosome Abnormalities Among Hypodiploid Patients
| Abnormality . | Karyotypic Group . | ||||
|---|---|---|---|---|---|
| 24-28 Chromosomes (N = 8) . | 33-44 Chromosomes No Dicentric (N = 13) . | 33-44 Chromosomes With Dicentric (N = 2) . | 45 Chromosomes No Dicentric (N = 59) . | 45 Chromosomes With Dicentric (N = 28) . | |
| Chromosome loss | |||||
| −7 | 8 (100) | 6 (46) | 1 (50) | 10 (17) | 0 (0) |
| −13 | 7 (88) | 6 (46) | 0 (0) | 11 (19) | 0 (0) |
| −14 | 6 (75) | 4 (38) | 0 (0) | 8 (14) | 0 (0) |
| −20 | 8 (100) | 5 (31) | 0 (0) | 8 (14) | 0 (0) |
| −X | 3 (38) | 3 (23) | 0 (0) | 10 (17) | 0 (0) |
| −Y | 1 (13) | 5 (38) | 0 (0) | 3 (5) | 0 (0) |
| Dicentric chromosome | |||||
| dic(9;12) | NA | NA | 1 (50) | NA | 10 (36) |
| dic(9;20) | NA | NA | 0 (0) | NA | 9 (32) |
| dic(7;9) | NA | NA | 0 (0) | NA | 4 (14) |
| dic(9;V) | NA | NA | 1 (50) | NA | 2 (7) |
| Other dicentric | NA | NA | 0 (0) | NA | 3 (11) |
| Other abnormality | |||||
| del(6q) | 8* (100) | 2 (15) | 0 (0) | 7 (12) | 1 (4) |
| Abnormal 9p | 8* (100) | 11 (85) | 2 (100) | 18 (31) | 25 (89) |
| Abnormal 12p | 8* (100) | 6 (46) | 2 (100) | 13 (22) | 11 (39) |
| Philadelphia chromosome | |||||
| Monosomy 7 | 0 (0) | 1 (8) | 0 (0) | 3 (5) | 0 (0) |
| Disomy 7 | 0 (0) | 0 (0) | 0 (0) | 2 (3) | 1 (4) |
| One aberration | NA† | NA† | NA† | 6 (10) | 13 (46) |
| Two aberrations | NA† | 0 (0) | 1 (50) | 16 (27) | 7 (25) |
| ≥Three aberrations | 8 (100) | 13 (100) | 1 (50) | 37 (63) | 8 (29) |
| Doubling of abnormal clone | 2 (25) | 2 (15) | 0 (0) | 0 (0) | 0 (0) |
| Numerical abnormality only | 5 (63) | 2 (15) | 0 (0) | 6 (10) | 0 (0) |
| Abnormality . | Karyotypic Group . | ||||
|---|---|---|---|---|---|
| 24-28 Chromosomes (N = 8) . | 33-44 Chromosomes No Dicentric (N = 13) . | 33-44 Chromosomes With Dicentric (N = 2) . | 45 Chromosomes No Dicentric (N = 59) . | 45 Chromosomes With Dicentric (N = 28) . | |
| Chromosome loss | |||||
| −7 | 8 (100) | 6 (46) | 1 (50) | 10 (17) | 0 (0) |
| −13 | 7 (88) | 6 (46) | 0 (0) | 11 (19) | 0 (0) |
| −14 | 6 (75) | 4 (38) | 0 (0) | 8 (14) | 0 (0) |
| −20 | 8 (100) | 5 (31) | 0 (0) | 8 (14) | 0 (0) |
| −X | 3 (38) | 3 (23) | 0 (0) | 10 (17) | 0 (0) |
| −Y | 1 (13) | 5 (38) | 0 (0) | 3 (5) | 0 (0) |
| Dicentric chromosome | |||||
| dic(9;12) | NA | NA | 1 (50) | NA | 10 (36) |
| dic(9;20) | NA | NA | 0 (0) | NA | 9 (32) |
| dic(7;9) | NA | NA | 0 (0) | NA | 4 (14) |
| dic(9;V) | NA | NA | 1 (50) | NA | 2 (7) |
| Other dicentric | NA | NA | 0 (0) | NA | 3 (11) |
| Other abnormality | |||||
| del(6q) | 8* (100) | 2 (15) | 0 (0) | 7 (12) | 1 (4) |
| Abnormal 9p | 8* (100) | 11 (85) | 2 (100) | 18 (31) | 25 (89) |
| Abnormal 12p | 8* (100) | 6 (46) | 2 (100) | 13 (22) | 11 (39) |
| Philadelphia chromosome | |||||
| Monosomy 7 | 0 (0) | 1 (8) | 0 (0) | 3 (5) | 0 (0) |
| Disomy 7 | 0 (0) | 0 (0) | 0 (0) | 2 (3) | 1 (4) |
| One aberration | NA† | NA† | NA† | 6 (10) | 13 (46) |
| Two aberrations | NA† | 0 (0) | 1 (50) | 16 (27) | 7 (25) |
| ≥Three aberrations | 8 (100) | 13 (100) | 1 (50) | 37 (63) | 8 (29) |
| Doubling of abnormal clone | 2 (25) | 2 (15) | 0 (0) | 0 (0) | 0 (0) |
| Numerical abnormality only | 5 (63) | 2 (15) | 0 (0) | 6 (10) | 0 (0) |