Table 2.

Predictors of time to CR (TC) and residual survival time after CR (TC,D) under the multivariate model

Covariate Effect on TCPEffect on TC,DP
De Novo Acute Myeloid  
  Leukemia* 
Increasing age  TClonger  .011  TC,D shorter  .002  
 Inv(16) or t(8;21)  TC shorter  .614  TC,D longer <.001  
 Other abnormal Cytogenetics TC longer  .607  TC,D shorter .465  
 HDAC  TC shorter  .289 TC,D shorter  .172  
 Fludarabine + HDAC TC shorter  .194  TC,D shorter .999  
Acute myeloid leukemia  arising after AHD; RAEB, RAEB-t† 
Increasing age  TC longer  .317 TC,D shorter  .046  
 Inv(16) or t(8;21) TC shorter  .332  TC,D shorter .950  
 Other abnormal Cytogenetics TC longer  .209  TC,D shorter <.001  
 HDAC  TC shorter  .387 TC,D longer  .022  
 Fludarabine + HDAC TC shorter  .621  TC,D longer .062 
Covariate Effect on TCPEffect on TC,DP
De Novo Acute Myeloid  
  Leukemia* 
Increasing age  TClonger  .011  TC,D shorter  .002  
 Inv(16) or t(8;21)  TC shorter  .614  TC,D longer <.001  
 Other abnormal Cytogenetics TC longer  .607  TC,D shorter .465  
 HDAC  TC shorter  .289 TC,D shorter  .172  
 Fludarabine + HDAC TC shorter  .194  TC,D shorter .999  
Acute myeloid leukemia  arising after AHD; RAEB, RAEB-t† 
Increasing age  TC longer  .317 TC,D shorter  .046  
 Inv(16) or t(8;21) TC shorter  .332  TC,D shorter .950  
 Other abnormal Cytogenetics TC longer  .209  TC,D shorter <.001  
 HDAC  TC shorter  .387 TC,D longer  .022  
 Fludarabine + HDAC TC shorter  .621  TC,D longer .062 
*

Association parameter between TC and TC,D= −0.543 (P = .0004).

†

Association parameter between TC and TC,D = −0.355 (P = .133).

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