Published Data of Frequencies of Variant Genotypes of the Low-Affinity Fcγ Receptors
| FcγRIIa Population . | No. . | HH . | HR . | RR . | Comparison With Other Populations6-150 . | Reference . |
|---|---|---|---|---|---|---|
| CA | (P) | |||||
| UK | 259 | 57 (22%) | 120 (46%) | 82 (32%) | (.0067) | Botto38 |
| Germany | 256 | 71 (28%) | 134 (52%) | 51 (20%) | Carlsson66 | |
| France | 218 | 75 (34%) | 99 (45%) | 44 (21%) | (.0093) | Bachelot-Loza39 |
| Germany | 187 | 53 (28%) | 84 (45%) | 50 (27%) | Manger40 | |
| United States | 149 | 38 (26%) | 79 (53%) | 32 (21%) | Edberg41 | |
| Netherlands | 123 | 36 (29%) | 59 (48%) | 28 (23%) | Sanders42 | |
| Russia | 107 | 30 (28%) | 58 (54%) | 19 (18%) | Platonov43 | |
| United States6-151 | 102 | 20 (20%) | 56 (55%) | 26 (25%) | Arepally44 | |
| United States | 100 | 19 (19%) | 49 (49%) | 32 (32%) | Brandt45 | |
| Canada | 100 | 26 (26%) | 52 (52%) | 22 (22%) | Horsewood46 | |
| Canada | 95 | 20 (21%) | 49 (52%) | 26 (27%) | Denomme47 | |
| Finland | 93 | 25 (27%) | 55 (59%) | 13 (14%) | Joutsi48 | |
| Netherlands | 87 | 24 (28%) | 44 (50%) | 19 (22%) | Koene61 | |
| Netherlands | 69 | 22 (32%) | 36 (52%) | 11 (16%) | Duits49 | |
| UK | 66 | 12 (18%) | 38 (58%) | 16 (24%) | Smyth50 | |
| Ireland | 61 | 15 (25%) | 35 (57%) | 11 (18%) | Williams51 | |
| United States6-152 | 56 | 11 (20%) | 26 (46%) | 19 (34%) | Abadi52 | |
| United States6-152 | 56 | 11 (20%) | 30 (54%) | 15 (27%) | Salmon53 | |
| Greece | 52 | 20 (39%) | 24 (46%) | 8 (15%) | Smyth50 | |
| Norway | 49 | 9 (18%) | 18 (37%) | 22 (45%) | (.0023) | Raknes32 |
| United States | 47 | 14 (30%) | 24 (51%) | 9 (19%) | Reilly54 | |
| UK | 40 | 9 (23%) | 22 (55%) | 9 (23%) | Caliz (a)55 | |
| United States | 35 | 8 (23%) | 19 (54%) | 8 (23%) | Osborne56 | |
| Australia | 22 | 2 (9%) | 13 (60%) | 7 (31%) | Burgess57 | |
| Total | 2419 | 627 (26%) | 1,223 (50%) | 579 (24%) | ||
| 6-153(χ2 = 3.99, P = .14v CA of Table 1) | ||||||
| FcγRIIa Population | No. | HH | HR | RR | Reference | |
| AA | ||||||
| United States | 100 | 27 (27%) | 50 (50%) | 23 (23%) | Salmon58 | |
| Caribbean | 77 | 17 (22%) | 35 (45%) | 25 (33%) | Botto38 | |
| United States | 50 | 7 (14%) | 30 (60%) | 13 (26%) | Reilly54 | |
| Norris59 | ||||||
| Total | 227 | 51 (22%) | 115 (51%) | 61 (27%) | ||
| 6-153(χ2 = 2.32, P = .31v AA of Table 1) | ||||||
| FcγRIIa Population | No. | HH | HR | RR | Reference | |
| Far East | ||||||
| Japan | 105 | 63 (60%) | 38 (36%) | 4 (4%) | Kobayashi31 | |
| Korea | 64 | 22 (34%) | 37 (58%) | 5 (8%) | Song60 | |
| China | 49 | 24 (49%) | 20 (41%) | 5 (10%) | Botto38 | |
| China | 18 | 9 (50%) | 8 (44%) | 1 (6%) | Osborne56 | |
| Japan | 18 | 11 (61%) | 6 (33%) | 1 (6%) | Osborne56 | |
| India | 16 | 2 (13%) | 9 (56%) | 5 (31%) | Osborne56 | |
| Total | 270 | 131 (49%) | 118 (43%) | 21 (8%) | ||
| FcγRIIIa Population | No. | FF | VF | VV | Reference | |
| CA | ||||||
| United States6-155 | 200 | 87 (43%) | 92 (46%) | 21 (11%) | Wu24 | |
| Netherlands | 87 | 28 (32%) | 44 (51%) | 15 (17%) | Koene23 | |
| Total | 287 | 115 (40%) | 136 (47%) | 36 (13%) | ||
| 6-153(χ2 = 4.69, P = .10v CA in Table 1) | ||||||
| FcγRIIa Population . | No. . | HH . | HR . | RR . | Comparison With Other Populations6-150 . | Reference . |
|---|---|---|---|---|---|---|
| CA | (P) | |||||
| UK | 259 | 57 (22%) | 120 (46%) | 82 (32%) | (.0067) | Botto38 |
| Germany | 256 | 71 (28%) | 134 (52%) | 51 (20%) | Carlsson66 | |
| France | 218 | 75 (34%) | 99 (45%) | 44 (21%) | (.0093) | Bachelot-Loza39 |
| Germany | 187 | 53 (28%) | 84 (45%) | 50 (27%) | Manger40 | |
| United States | 149 | 38 (26%) | 79 (53%) | 32 (21%) | Edberg41 | |
| Netherlands | 123 | 36 (29%) | 59 (48%) | 28 (23%) | Sanders42 | |
| Russia | 107 | 30 (28%) | 58 (54%) | 19 (18%) | Platonov43 | |
| United States6-151 | 102 | 20 (20%) | 56 (55%) | 26 (25%) | Arepally44 | |
| United States | 100 | 19 (19%) | 49 (49%) | 32 (32%) | Brandt45 | |
| Canada | 100 | 26 (26%) | 52 (52%) | 22 (22%) | Horsewood46 | |
| Canada | 95 | 20 (21%) | 49 (52%) | 26 (27%) | Denomme47 | |
| Finland | 93 | 25 (27%) | 55 (59%) | 13 (14%) | Joutsi48 | |
| Netherlands | 87 | 24 (28%) | 44 (50%) | 19 (22%) | Koene61 | |
| Netherlands | 69 | 22 (32%) | 36 (52%) | 11 (16%) | Duits49 | |
| UK | 66 | 12 (18%) | 38 (58%) | 16 (24%) | Smyth50 | |
| Ireland | 61 | 15 (25%) | 35 (57%) | 11 (18%) | Williams51 | |
| United States6-152 | 56 | 11 (20%) | 26 (46%) | 19 (34%) | Abadi52 | |
| United States6-152 | 56 | 11 (20%) | 30 (54%) | 15 (27%) | Salmon53 | |
| Greece | 52 | 20 (39%) | 24 (46%) | 8 (15%) | Smyth50 | |
| Norway | 49 | 9 (18%) | 18 (37%) | 22 (45%) | (.0023) | Raknes32 |
| United States | 47 | 14 (30%) | 24 (51%) | 9 (19%) | Reilly54 | |
| UK | 40 | 9 (23%) | 22 (55%) | 9 (23%) | Caliz (a)55 | |
| United States | 35 | 8 (23%) | 19 (54%) | 8 (23%) | Osborne56 | |
| Australia | 22 | 2 (9%) | 13 (60%) | 7 (31%) | Burgess57 | |
| Total | 2419 | 627 (26%) | 1,223 (50%) | 579 (24%) | ||
| 6-153(χ2 = 3.99, P = .14v CA of Table 1) | ||||||
| FcγRIIa Population | No. | HH | HR | RR | Reference | |
| AA | ||||||
| United States | 100 | 27 (27%) | 50 (50%) | 23 (23%) | Salmon58 | |
| Caribbean | 77 | 17 (22%) | 35 (45%) | 25 (33%) | Botto38 | |
| United States | 50 | 7 (14%) | 30 (60%) | 13 (26%) | Reilly54 | |
| Norris59 | ||||||
| Total | 227 | 51 (22%) | 115 (51%) | 61 (27%) | ||
| 6-153(χ2 = 2.32, P = .31v AA of Table 1) | ||||||
| FcγRIIa Population | No. | HH | HR | RR | Reference | |
| Far East | ||||||
| Japan | 105 | 63 (60%) | 38 (36%) | 4 (4%) | Kobayashi31 | |
| Korea | 64 | 22 (34%) | 37 (58%) | 5 (8%) | Song60 | |
| China | 49 | 24 (49%) | 20 (41%) | 5 (10%) | Botto38 | |
| China | 18 | 9 (50%) | 8 (44%) | 1 (6%) | Osborne56 | |
| Japan | 18 | 11 (61%) | 6 (33%) | 1 (6%) | Osborne56 | |
| India | 16 | 2 (13%) | 9 (56%) | 5 (31%) | Osborne56 | |
| Total | 270 | 131 (49%) | 118 (43%) | 21 (8%) | ||
| FcγRIIIa Population | No. | FF | VF | VV | Reference | |
| CA | ||||||
| United States6-155 | 200 | 87 (43%) | 92 (46%) | 21 (11%) | Wu24 | |
| Netherlands | 87 | 28 (32%) | 44 (51%) | 15 (17%) | Koene23 | |
| Total | 287 | 115 (40%) | 136 (47%) | 36 (13%) | ||
| 6-153(χ2 = 4.69, P = .10v CA in Table 1) | ||||||
| FcγRIIIb Population . | No. . | NA1NA1 . | NA1NA2 . | NA2NA2 . | . | Reference . |
|---|---|---|---|---|---|---|
| CA | ||||||
| United States6-152 | 99 | 17 (17%) | 71 (72%) | 11 (11%) | Hessner35 | |
| United States | 90 | 10 (11%) | 46 (51%) | 34 (38%) | Hessner35 | |
| Netherlands | 87 | 11 (12%) | 39 (45%) | 37 (43%) | Koene61 | |
| United States6-151 | 67 | 10 (15%) | 30 (45%) | 27 (40%) | Wainstein62 | |
| Norway | 49 | 4 (8%) | 28 (57%) | 17 (35%) | Raknes32 | |
| Total | 392 | 52 (13%) | 214 (55%) | 126 (32%) | ||
| 6-153,6-154(χ2 = 7.32, P = .026v CA in Table 1) | ||||||
| FcγRIIIb Population | No. | NA1NA1 | NA1NA2 | NA2NA2 | Reference | |
| Far East | ||||||
| India | 92 | 15 (16%) | 26 (28%) | 51 (55%) | Hessner35 | |
| Native American | ||||||
| United States | 98 | 20 (20%) | 71 (71%) | 9 (9%) | Hessner35 | |
| 6-153AA | ||||||
| United States | 99 | 16 (16%) | 30 (30%) | 54 (54%) | Hessner35 | |
| 6-153(χ2 = 10.25, P = .006v AA in Table 1) | ||||||
| FcγRIIIb Population . | No. . | NA1NA1 . | NA1NA2 . | NA2NA2 . | . | Reference . |
|---|---|---|---|---|---|---|
| CA | ||||||
| United States6-152 | 99 | 17 (17%) | 71 (72%) | 11 (11%) | Hessner35 | |
| United States | 90 | 10 (11%) | 46 (51%) | 34 (38%) | Hessner35 | |
| Netherlands | 87 | 11 (12%) | 39 (45%) | 37 (43%) | Koene61 | |
| United States6-151 | 67 | 10 (15%) | 30 (45%) | 27 (40%) | Wainstein62 | |
| Norway | 49 | 4 (8%) | 28 (57%) | 17 (35%) | Raknes32 | |
| Total | 392 | 52 (13%) | 214 (55%) | 126 (32%) | ||
| 6-153,6-154(χ2 = 7.32, P = .026v CA in Table 1) | ||||||
| FcγRIIIb Population | No. | NA1NA1 | NA1NA2 | NA2NA2 | Reference | |
| Far East | ||||||
| India | 92 | 15 (16%) | 26 (28%) | 51 (55%) | Hessner35 | |
| Native American | ||||||
| United States | 98 | 20 (20%) | 71 (71%) | 9 (9%) | Hessner35 | |
| 6-153AA | ||||||
| United States | 99 | 16 (16%) | 30 (30%) | 54 (54%) | Hessner35 | |
| 6-153(χ2 = 10.25, P = .006v AA in Table 1) | ||||||
The distribution of genotypes in each individual study was compared with the overall distribution of remaining published populations (including the population reported here) in a 3 × 2 χ2 analysis (with 2 degrees of freedom). Studies listed more than once report distinct populations in the paper and are treated as separate populations for the purpose of the analysis. Only significant values are shown in the table. (a) indicates data presented in abstract form only.
Race not specified.
Hispanic and/or Mexican American.
Comparison of data presented in Table 1 with the sum of the published studies.
Ethnically diverse.
When the Hispanic population reported by Hessner35 is excluded from the analysis, there is no significant difference (NA1/NA1, 35 [12%]; NA1/NA2, 143 [49%]; NA2/NA2, 115 [39%]; χ2 = 1.02, P = .60 v CA in Table 1).