Table 1. Genotype and Blood Phenotype of... | American Society of Hematology

Table 1.

Genotype and Blood Phenotype of Offspring From Lox-Piga-lacZ X EIIa-cre Breeding

Breeding Parents	Mother Father	EL	LE
Breeding Parents	Mother Father	EIIa-cre(+/+) Lox-Piga-LacZ (+)	Lox-Piga-lacZ(+/−) Ella-cre(+/+)
No. of litters		16	8
No. of pups		156	54
No. of pups alive after 48 h		132	53
Male:female ratio		1.8	0.86
Males:	Total	85 (64%)	25 (47%)
	Lox-Piga-lacZ(+)EIIa-cre(−/+) genotype	0	10 (19%)
	>2% PIGA(−) RBCs^*	NA	10 (19%)
	>5% PIGA(−) white cells^†	NA	3 (6%)
Females:	Total	47 (36%)	28 (53%)
	Lox-Piga-lacZ(+/−)EIIa-cre(−/+) genotype	47 (36%)	10 (19%)
	>2% PIGA(−) RBCs^*	35 (27%)	10 (19%)
	>5% PIGA(−) white cells^†	28 (21%)	8 (15%)

Breeding Parents	Mother Father	EL	LE
Breeding Parents	Mother Father	EIIa-cre(+/+) Lox-Piga-LacZ (+)	Lox-Piga-lacZ(+/−) Ella-cre(+/+)
No. of litters		16	8
No. of pups		156	54
No. of pups alive after 48 h		132	53
Male:female ratio		1.8	0.86
Males:	Total	85 (64%)	25 (47%)
	Lox-Piga-lacZ(+)EIIa-cre(−/+) genotype	0	10 (19%)
	>2% PIGA(−) RBCs^*	NA	10 (19%)
	>5% PIGA(−) white cells^†	NA	3 (6%)
Females:	Total	47 (36%)	28 (53%)
	Lox-Piga-lacZ(+/−)EIIa-cre(−/+) genotype	47 (36%)	10 (19%)
	>2% PIGA(−) RBCs^*	35 (27%)	10 (19%)
	>5% PIGA(−) white cells^†	28 (21%)	8 (15%)

Numbers in parentheses refer to the percentage of pups alive after 48 hours.

Abbreviation: NA, not applicable.

At age of 24-48 h.

At the age of 4 weeks.