Demographic Data of 319 Children Receiving 352 Courses of Warfarin
| Predictor . | No. of Courses of Warfarin . | Mean Age in Years . | Length of Treatment in Months . | Actual INRs . |
|---|---|---|---|---|
| INR | ||||
| 1.4-1.8 | 52 | 10.8 ± 6.3 | 20 ± 17.5 | 1.58 ± 0.10 |
| 2.0-3.0 | 263 | 7.1 ± 5.9 | 9 ± 12.5 | 2.35 ± 0.17 |
| 2.5-3.5 | 37 | 12.0 ± 5.8 | 36 ± 22.4 | 2.59 ± 0.20 |
| P value | NS | NS | <.0001 | |
| Age in years | ||||
| ≤1 | 43 | 0.7 ± 0.3 | 5 ± 7.5 | 2.3 ± 0.3 |
| >1 < 6 | 123 | 3.0 ± 1.0 | 8 ± 9.0 | 2.3 ± 0.2 |
| ≥6 < 13 | 74 | 9.3 ± 1.9 | 15 ± 17.8 | 2.2 ± 0.3 |
| ≥13 ≤ 18 | 112 | 16.0 ± 1.6 | 22 ± 21.2 | 2.2 ± 0.4 |
| P value | NS | NS | NS | |
| Disease* | ||||
| CHD (n = 114) | 121 | 6.0 ± 5.6 | 10.8 ± 13.8 | 2.3 ± 0.2 |
| Non-CHD (n = 155) | 181 | 10.8 ± 6.0 | 17.7 ± 19.7 | 2.2 ± 0.4 |
| Fontan (n = 50) | 50 | 4.0 ± 3.0 | 5.2 ± 4.1 | 2.3 ± 0.1 |
| P value | NS | NS | NS | |
| Medication | ||||
| Corticosteroids | ||||
| Yes | 38 | 11.0 ± 5.9 | 15.9 ± 16.9 | 2.1 ± 0.4 |
| No | 314 | 7.8 ± 6.1 | 13.3 ± 17.0 | 2.3 ± 0.3 |
| P value | NS | NS | .05 | |
| Phenobarbital/ Carbamazepine | ||||
| Yes | 10 | 10.0 ± 7.7 | 27.4 ± 23.7 | 2.2 ± 0.4 |
| No | 342 | 8.1 ± 6.1 | 13.1 ± 16.6 | 2.3 ± 0.3 |
| P value | NS | NS | NS | |
| Diet | ||||
| Enteral nutrition | ||||
| Yes | 82 | 2.5 ± 2.8 | 8.3 ± 10.0 | 2.3 ± 0.3 |
| No | 270 | 10.0 ± 5.9 | 15.2 ± 18.3 | 2.2 ± 0.3 |
| P value | NS | NS | NS |
| Predictor . | No. of Courses of Warfarin . | Mean Age in Years . | Length of Treatment in Months . | Actual INRs . |
|---|---|---|---|---|
| INR | ||||
| 1.4-1.8 | 52 | 10.8 ± 6.3 | 20 ± 17.5 | 1.58 ± 0.10 |
| 2.0-3.0 | 263 | 7.1 ± 5.9 | 9 ± 12.5 | 2.35 ± 0.17 |
| 2.5-3.5 | 37 | 12.0 ± 5.8 | 36 ± 22.4 | 2.59 ± 0.20 |
| P value | NS | NS | <.0001 | |
| Age in years | ||||
| ≤1 | 43 | 0.7 ± 0.3 | 5 ± 7.5 | 2.3 ± 0.3 |
| >1 < 6 | 123 | 3.0 ± 1.0 | 8 ± 9.0 | 2.3 ± 0.2 |
| ≥6 < 13 | 74 | 9.3 ± 1.9 | 15 ± 17.8 | 2.2 ± 0.3 |
| ≥13 ≤ 18 | 112 | 16.0 ± 1.6 | 22 ± 21.2 | 2.2 ± 0.4 |
| P value | NS | NS | NS | |
| Disease* | ||||
| CHD (n = 114) | 121 | 6.0 ± 5.6 | 10.8 ± 13.8 | 2.3 ± 0.2 |
| Non-CHD (n = 155) | 181 | 10.8 ± 6.0 | 17.7 ± 19.7 | 2.2 ± 0.4 |
| Fontan (n = 50) | 50 | 4.0 ± 3.0 | 5.2 ± 4.1 | 2.3 ± 0.1 |
| P value | NS | NS | NS | |
| Medication | ||||
| Corticosteroids | ||||
| Yes | 38 | 11.0 ± 5.9 | 15.9 ± 16.9 | 2.1 ± 0.4 |
| No | 314 | 7.8 ± 6.1 | 13.3 ± 17.0 | 2.3 ± 0.3 |
| P value | NS | NS | .05 | |
| Phenobarbital/ Carbamazepine | ||||
| Yes | 10 | 10.0 ± 7.7 | 27.4 ± 23.7 | 2.2 ± 0.4 |
| No | 342 | 8.1 ± 6.1 | 13.1 ± 16.6 | 2.3 ± 0.3 |
| P value | NS | NS | NS | |
| Diet | ||||
| Enteral nutrition | ||||
| Yes | 82 | 2.5 ± 2.8 | 8.3 ± 10.0 | 2.3 ± 0.3 |
| No | 270 | 10.0 ± 5.9 | 15.2 ± 18.3 | 2.2 ± 0.3 |
| P value | NS | NS | NS |
Data are reported as mean ± 1 SD.
Abbreviations: CHD, congenital heart disease; n, number; NS, not significant.
n represents number of children. Thirty children received more than 1 course of warfarin therapy.