Table 2. Range of In Situ TSI 50 Values... | American Society of Hematology

Table 2.

Range of In Situ TSI₅₀ Values for Novel Antifolates in Clinical Leukemia Samples and Plasma Levels Obtained in Phase I/II Clinical Trials

	TSI_cont (μmol/L)	TSI_short (μmol/L)	Plasma Levels	Trial	Reference
MTX	0.01-0.78	<0.16 − >40.0	25 μmol/L	Children	Evans et al⁴⁹
TMQ	<0.0016-0.16	<0.08-14.3	7 μmol/L	Children	Hum et al⁴⁵
GW1843	<0.00025-0.047	<0.0010 >0.63	3 μmol/L	Adults	Burris et al⁵⁰
MTA	<0.039 − >10.0	<0.039 − >10.0	300 μmol/L	Adults	Rinaldi⁵¹
Raltitrexed	0.0014-0.092	0.0043 − >0.32	3 μmol/L	Children	Widemann et al⁴⁶
ZD9331	0.0016-0.19	0.9 − >25.0	No data published

	TSI_cont (μmol/L)	TSI_short (μmol/L)	Plasma Levels	Trial	Reference
MTX	0.01-0.78	<0.16 − >40.0	25 μmol/L	Children	Evans et al⁴⁹
TMQ	<0.0016-0.16	<0.08-14.3	7 μmol/L	Children	Hum et al⁴⁵
GW1843	<0.00025-0.047	<0.0010 >0.63	3 μmol/L	Adults	Burris et al⁵⁰
MTA	<0.039 − >10.0	<0.039 − >10.0	300 μmol/L	Adults	Rinaldi⁵¹
Raltitrexed	0.0014-0.092	0.0043 − >0.32	3 μmol/L	Children	Widemann et al⁴⁶
ZD9331	0.0016-0.19	0.9 − >25.0	No data published