Table 4. Comparative Expression of... | American Society of Hematology

Table 4.

Comparative Expression of CD45R0 by CD59⁺(Normal) and CD59⁻ (GPI-Deficient) Components of CD4⁺ and CD8⁺ T-Cell Subpopulations in Patients With PNH

Patient ID	CD4⁺ Lymphocytes^4-150		CD8⁺ Lymphocytes^4-150
Patient ID	CD59⁺ CD45R0⁺ %	CD59⁻ CD45R0⁺ %	CD59⁺ CD45R0⁺ %	CD59⁻ CD45R0⁺ %
PNH007	76	24	63	48
PNH020	44	17	56	2
PNH022	83	35	53	10
PNH033	63	24	59	8
PNH042	77	30	64	15
PNH055	37	8	14	8
PNH058	49	8	40	12
PNH079	45	22	46	10
PNH087	57	5	20	3
PNH090	55	7	33	11
PNH091	84	28	76	47
Median	57	22	53	10
Normal range^4-151	51-68	NA	18-46	NA

Patient ID	CD4⁺ Lymphocytes^4-150		CD8⁺ Lymphocytes^4-150
Patient ID	CD59⁺ CD45R0⁺ %	CD59⁻ CD45R0⁺ %	CD59⁺ CD45R0⁺ %	CD59⁻ CD45R0⁺ %
PNH007	76	24	63	48
PNH020	44	17	56	2
PNH022	83	35	53	10
PNH033	63	24	59	8
PNH042	77	30	64	15
PNH055	37	8	14	8
PNH058	49	8	40	12
PNH079	45	22	46	10
PNH087	57	5	20	3
PNH090	55	7	33	11
PNH091	84	28	76	47
Median	57	22	53	10
Normal range^4-151	51-68	NA	18-46	NA

As determined by three-color flow cytometry using CD59/CD45R0/CD4 and CD59/CD45R0/CD8 combinations of monoclonal antibodies as described in Materials and Methods section. Values in the table are the percentage of either CD59⁺ or CD459⁻ cells expressing CD45R0 determinants.

Abbreviation: NA, not applicable.

F4-150

T-cell subpopulations identified on the basis of strong CD4 or CD8 positivity and low SSC characteristics. Statistical comparisons were made using a paired t test. Statistically significant differences in expression of CD45R0 were shown between CD59⁺ and CD59⁻ lymphocytes.

F4-151

Normal range for CD45R0 expression by T cells derived from analysis of 12 normal adult controls.

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