Table 2. Comparative Expression of... | American Society of Hematology

Table 2.

Comparative Expression of CD45RA and HLADR by CD48⁺ (Normal) and CD48⁻ (GPI-Deficient) Subpopulations of T Cells in Patients With PNH

Patient ID	T Cells (CD3⁺)^*
Patient ID	CD48⁺ CD45RA⁺ %	CD48⁻ CD45RA⁺ %	CD48⁺ HLADR⁺ %	CD48⁻ HLADR⁺ %
PNH003	56	74	39	6
PNH007	65	94	29	16
PNH008	37	85	12	3
PNH012	48	87	32	3
PNH019	25	75	ND	ND
PNH022	37	82	24	5
PNH034	44	83	12	6
PNH043	57	89	23	4
PNH055	71	95	11	4
PNH063	20	62	23	17
PNH072	56	93	ND	ND
PNH079	42	72	23	13
PNH087	62	94	16	4
PNH090	61	91	5	1
PNH091	20	62	17	2
Normal range^†	ND	NA	<20	NA

Patient ID	T Cells (CD3⁺)^*
Patient ID	CD48⁺ CD45RA⁺ %	CD48⁻ CD45RA⁺ %	CD48⁺ HLADR⁺ %	CD48⁻ HLADR⁺ %
PNH003	56	74	39	6
PNH007	65	94	29	16
PNH008	37	85	12	3
PNH012	48	87	32	3
PNH019	25	75	ND	ND
PNH022	37	82	24	5
PNH034	44	83	12	6
PNH043	57	89	23	4
PNH055	71	95	11	4
PNH063	20	62	23	17
PNH072	56	93	ND	ND
PNH079	42	72	23	13
PNH087	62	94	16	4
PNH090	61	91	5	1
PNH091	20	62	17	2
Normal range^†	ND	NA	<20	NA

As determined by three-color flow cytometry using CD48/CD45RA/CD3 and HLA-DR/CD48/CD3 combinations of monoclonal antibodies as described in Materials and Methods section. Values in the table are the percentage of either CD48⁺ or CD48⁻ cells expressing either CD45RA or HLA-DR determinants.

Abbreviations: ND, not determined; NA, not applicable.

T cells identified on the basis of strong CD3 positivity and low SSC characteristics. Statistical comparisons were made using a pairedt test: Statistically significant differences in expression of CD45RA and HLA-DR were shown between CD48⁺ and CD48⁻ lymphocytes.

†

Normal range for HLA-DR expression by T cells derived from analysis of 27 normal adult controls.

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