Clinical and Laboratory Features of Patients Studied
| Patient ID . | Age (yrs)/ Sex . | Clinical Features* . | GPI-Deficient Clone (%)† . | CD4 Count/ (109/L)‡ . | CD8 Count/ (109/L)‡ . | ||
|---|---|---|---|---|---|---|---|
| Granulocytes . | Red Blood Cells . | T Cells . | |||||
| PNH003 | 39/M | Hypoplastic | 5.9 | 2.2 | 0.2 | 0.39 | 0.90 |
| PNH007 | 29/F | Hemolytic | 96.2 | 52.5 | 30.4 | 0.45 | 0.63 |
| PNH008 | 29/F | Was hemolytic1-153 | 1.4 | 0.5 | 21.8 | 0.74 | 1.09 |
| PNH012 | 33/F | Hypoplastic | 44.3 | 49.8 | 24.2 | 0.61 | 0.64 |
| PNH019 | 45/M | Hemolytic | 81.7 | 32.0 | 9.9 | 0.99 | 0.64 |
| PNH020 | 25/M | Hypoplastic | 95.4 | 73.8 | 16.8 | 0.64 | 0.31 |
| PNH022 | 44/F | Hemolytic | 93.0 | 20.9 | 8.7 | 0.33 | 0.20 |
| PNH027 | 74/M | Hemolytic | 99.6 | 89.6 | 0.3 | 0.32 | 0.08 |
| PNH030 | 66/F | Spontaneous remission 20 years ago | <0.1 | <0.1 | 9.4 | 0.86 | 0.66 |
| PNH033 | 34/F | Hemolytic | 99.5 | 79.5 | 21.4 | 0.34 | 0.18 |
| PNH034 | 53/F | Hemolytic | 73.8 | 32.8 | 2.1 | 0.74 | 0.37 |
| PNH042 | 55/M | Hypoplastic | 94.9 | 48.8 | 0.6 | 0.47 | 0.39 |
| PNH043 | 43/M | Hypoplastic | 96.8 | 30.7 | 5.0 | 0.24 | 0.40 |
| PNH047 | 37/F | Hemolytic | 44.1 | 12.4 | 0.5 | 0.33 | 0.56 |
| PNH055 | 43/F | Hypoplastic | 76.3 | 5.4 | 5.5 | 1.07 | 0.63 |
| PNH058 | 25/F | Hemolytic | 95.3 | 57.3 | 6.8 | 0.94 | 0.34 |
| PNH063 | 37/F | Hypoplastic | 5.9 | 9.1 | 8.1 | 0.27 | 0.23 |
| PNH072 | 36/M | Hemolytic | 96.4 | 31.3 | 16.5 | 0.44 | 0.44 |
| PNH079 | 54/F | Hypoplastic | 95.9 | 84.9 | 17.8 | 0.40 | 0.21 |
| PNH087 | 24/M | Hypoplastic | 76.5 | 60.0 | 2.9 | 0.64 | 0.69 |
| PNH090 | 36/F | Hemolytic | 91.6 | 76.6 | 12.3 | 0.73 | 0.46 |
| PNH091 | 23/M | Hemolytic | 71.4 | 41.5 | 13.6 | 0.18 | 0.16 |
| Patient ID . | Age (yrs)/ Sex . | Clinical Features* . | GPI-Deficient Clone (%)† . | CD4 Count/ (109/L)‡ . | CD8 Count/ (109/L)‡ . | ||
|---|---|---|---|---|---|---|---|
| Granulocytes . | Red Blood Cells . | T Cells . | |||||
| PNH003 | 39/M | Hypoplastic | 5.9 | 2.2 | 0.2 | 0.39 | 0.90 |
| PNH007 | 29/F | Hemolytic | 96.2 | 52.5 | 30.4 | 0.45 | 0.63 |
| PNH008 | 29/F | Was hemolytic1-153 | 1.4 | 0.5 | 21.8 | 0.74 | 1.09 |
| PNH012 | 33/F | Hypoplastic | 44.3 | 49.8 | 24.2 | 0.61 | 0.64 |
| PNH019 | 45/M | Hemolytic | 81.7 | 32.0 | 9.9 | 0.99 | 0.64 |
| PNH020 | 25/M | Hypoplastic | 95.4 | 73.8 | 16.8 | 0.64 | 0.31 |
| PNH022 | 44/F | Hemolytic | 93.0 | 20.9 | 8.7 | 0.33 | 0.20 |
| PNH027 | 74/M | Hemolytic | 99.6 | 89.6 | 0.3 | 0.32 | 0.08 |
| PNH030 | 66/F | Spontaneous remission 20 years ago | <0.1 | <0.1 | 9.4 | 0.86 | 0.66 |
| PNH033 | 34/F | Hemolytic | 99.5 | 79.5 | 21.4 | 0.34 | 0.18 |
| PNH034 | 53/F | Hemolytic | 73.8 | 32.8 | 2.1 | 0.74 | 0.37 |
| PNH042 | 55/M | Hypoplastic | 94.9 | 48.8 | 0.6 | 0.47 | 0.39 |
| PNH043 | 43/M | Hypoplastic | 96.8 | 30.7 | 5.0 | 0.24 | 0.40 |
| PNH047 | 37/F | Hemolytic | 44.1 | 12.4 | 0.5 | 0.33 | 0.56 |
| PNH055 | 43/F | Hypoplastic | 76.3 | 5.4 | 5.5 | 1.07 | 0.63 |
| PNH058 | 25/F | Hemolytic | 95.3 | 57.3 | 6.8 | 0.94 | 0.34 |
| PNH063 | 37/F | Hypoplastic | 5.9 | 9.1 | 8.1 | 0.27 | 0.23 |
| PNH072 | 36/M | Hemolytic | 96.4 | 31.3 | 16.5 | 0.44 | 0.44 |
| PNH079 | 54/F | Hypoplastic | 95.9 | 84.9 | 17.8 | 0.40 | 0.21 |
| PNH087 | 24/M | Hypoplastic | 76.5 | 60.0 | 2.9 | 0.64 | 0.69 |
| PNH090 | 36/F | Hemolytic | 91.6 | 76.6 | 12.3 | 0.73 | 0.46 |
| PNH091 | 23/M | Hemolytic | 71.4 | 41.5 | 13.6 | 0.18 | 0.16 |
Hypoplastic patients defined by an absence of macroscopic hemoglobinuria.
GPI-deficient clones as measured by flow cytometry. Clone size includes both partially deficient (type II) and completely deficient (type III) populations.
References ranges: CD4 lymphocytes 0.53 to 1.75 × 109/L; CD8 lymphocytes 0.30 to 1.02 × 109/L.
Patient previously hemolytic with no hemolytic attacks since 1992 (spontaneous recovery).