Incidences of Venous Thromboembolism: Exposure to Inherited Antithrombin Deficiency and the Effect of Acquired or Genetic Risk Factors (Men and Women, Univariate)
| Acquired Risk Factor* . | Antithrombin Deficiency . | Years . | Patient . | VT† (%/yr) . | Ic† (95% CI) . |
|---|---|---|---|---|---|
| + | + | 69 | 14 | 20.3 | (12.0-34.3) |
| + | − | 81 | 1 | 1.2 | (0.2-8.8) |
| − | + | 1,534 | 4 | 0.3 | (0.1-0.7) |
| − | − | 1,820 | 0 | 0 | |
| Other Genetic Risk Factor‡ | Antithrombin Deficiency | Years | Patient | VT† (%/yr) | Ic† (95% CI) |
| + | + | 108 | 5 | 4.6 | (1.9-11.1) |
| + | − | 401 | 1 | 0.3 | (0.1-1.8) |
| − | + | 1,495 | 13 | 0.9 | (0.5-1.5) |
| − | − | 1,500 | 0 | 0 |
| Acquired Risk Factor* . | Antithrombin Deficiency . | Years . | Patient . | VT† (%/yr) . | Ic† (95% CI) . |
|---|---|---|---|---|---|
| + | + | 69 | 14 | 20.3 | (12.0-34.3) |
| + | − | 81 | 1 | 1.2 | (0.2-8.8) |
| − | + | 1,534 | 4 | 0.3 | (0.1-0.7) |
| − | − | 1,820 | 0 | 0 | |
| Other Genetic Risk Factor‡ | Antithrombin Deficiency | Years | Patient | VT† (%/yr) | Ic† (95% CI) |
| + | + | 108 | 5 | 4.6 | (1.9-11.1) |
| + | − | 401 | 1 | 0.3 | (0.1-1.8) |
| − | + | 1,495 | 13 | 0.9 | (0.5-1.5) |
| − | − | 1,500 | 0 | 0 |
Surgery, trauma, plaster cast, hospital admittance, immobilization more than 2 weeks before thrombosis. A time window of 1 year after the acquired risk situation was used.
Episodes of venous thromboembolism (VT), incidence rates per 100 patient years with 95% confidence intervals.
Factor V Leiden or PT20210A.