Toxic Effects During Induction Therapy
| Hematological Toxicity . | Median (range) . | N (%) . |
|---|---|---|
| Hematological recovery (days to) | ||
| PMN >1 × 109/L | 24 (5-57) | |
| Platelets >50 × 109/L | 19 (6-45) | |
| Fever | 115 (93) | |
| Not documented | 37 (32) | |
| Microbiologically documented without bacteremia | 11 (10) | |
| Bacteremia | 25 (22) | |
| Clinically documented | 42 (36) | |
| Hemorrhage | 82 (67) | |
| Pulmonary | 7 | |
| CNS | 6 | |
| Nonhematological toxicity (n = 103) Grades 3 and 4 (WHO) | ||
| Hepatic | 5 (5) | |
| Pulmonary | 17 (16) | |
| Renal | 1 (1) | |
| Cardiac | 6 (6) | |
| Neurological | 2 (2) | |
| Dermatological | 2 (2) | |
| Diarrhea | 3 (3) | |
| Oral | 15 (14) | |
| ATRA syndrome | ||
| Definitely present | 7 (6) | |
| Indeterminate | 25 (20) | |
| Definitely absent | 91 (74) |
| Hematological Toxicity . | Median (range) . | N (%) . |
|---|---|---|
| Hematological recovery (days to) | ||
| PMN >1 × 109/L | 24 (5-57) | |
| Platelets >50 × 109/L | 19 (6-45) | |
| Fever | 115 (93) | |
| Not documented | 37 (32) | |
| Microbiologically documented without bacteremia | 11 (10) | |
| Bacteremia | 25 (22) | |
| Clinically documented | 42 (36) | |
| Hemorrhage | 82 (67) | |
| Pulmonary | 7 | |
| CNS | 6 | |
| Nonhematological toxicity (n = 103) Grades 3 and 4 (WHO) | ||
| Hepatic | 5 (5) | |
| Pulmonary | 17 (16) | |
| Renal | 1 (1) | |
| Cardiac | 6 (6) | |
| Neurological | 2 (2) | |
| Dermatological | 2 (2) | |
| Diarrhea | 3 (3) | |
| Oral | 15 (14) | |
| ATRA syndrome | ||
| Definitely present | 7 (6) | |
| Indeterminate | 25 (20) | |
| Definitely absent | 91 (74) |