Baseline Characteristics of APL Patients and Remission Induction Results
| Characteristic . | Median (range) . | N (%) . | CR (%) . | P . |
|---|---|---|---|---|
| Age | 42 (1-74) | |||
| ≤15 | 7 (6) | 5 (71) | ||
| 16-40 | 49 (40) | 45 (92) | ||
| 41-60 | 46 (37) | 44 (96) | .007 | |
| 61-70 | 13 (11) | 11 (85) | ||
| >70 | 8 (6) | 4 (50) | ||
| Gender | ||||
| Male | 71 (58) | 61 (86) | NS | |
| Female | 52 (42) | 48 (92) | ||
| Fever | 41 (33) | 33 (80) | NS | |
| Organomegaly | 9 (7) | 8 (89) | NS | |
| Coagulopathy | 77 (63) | 70 (91) | NS | |
| Hemorrhage | 92 (75) | 80 (87) | NS | |
| Cutaneous | 74 (60) | |||
| Mucosal | 62 (50) | |||
| CNS | 2 (2) | |||
| Other | 20 (16) | |||
| WBC (×109/L) | 1.9 (0.4-210) | |||
| ≤3.5 | 78 (64) | 71 (91) | ||
| 3.5-10 | 15 (12) | 13 (87) | .02 | |
| 10-50 | 20 (16) | 19 (95) | ||
| >50 | 10 (8) | 6 (60) | ||
| Hemoglobin (g/dL) | 9.3 (4.4-13.1) | |||
| ≤10 | 78 (63) | 68 (87) | NS | |
| >10 | 45 (37) | 41 (91) | ||
| Platelets (×109/L) | 21 (1-161) | |||
| ≤10 | 23 (19) | 18 (78) | ||
| 11-50 | 76 (63) | 69 (91) | NS | |
| >50 | 22 (18) | 21 (95) | ||
| FAB subtype | ||||
| Typical | 100 (81) | 90 (90) | NS | |
| Variant | 23 (19) | 19 (83) | ||
| Cytogenetics (n = 94) | ||||
| Normal | 4 (4) | 4 (100) | ||
| t(15;17) | 68 (72) | 58 (88) | NS | |
| t(15;17), +8 | 10 (11) | 10 (100) | ||
| t(15;17), plus other abnormality | 9 (10) | 9 (100) | ||
| Other | 3 (3) | 3 (100) | ||
| PML/RARα (n = 121) | ||||
| BCR1/BCR2 | 68 (56) | 60 (88) | NS | |
| BCR3 | 53 (44) | 47 (89) |
| Characteristic . | Median (range) . | N (%) . | CR (%) . | P . |
|---|---|---|---|---|
| Age | 42 (1-74) | |||
| ≤15 | 7 (6) | 5 (71) | ||
| 16-40 | 49 (40) | 45 (92) | ||
| 41-60 | 46 (37) | 44 (96) | .007 | |
| 61-70 | 13 (11) | 11 (85) | ||
| >70 | 8 (6) | 4 (50) | ||
| Gender | ||||
| Male | 71 (58) | 61 (86) | NS | |
| Female | 52 (42) | 48 (92) | ||
| Fever | 41 (33) | 33 (80) | NS | |
| Organomegaly | 9 (7) | 8 (89) | NS | |
| Coagulopathy | 77 (63) | 70 (91) | NS | |
| Hemorrhage | 92 (75) | 80 (87) | NS | |
| Cutaneous | 74 (60) | |||
| Mucosal | 62 (50) | |||
| CNS | 2 (2) | |||
| Other | 20 (16) | |||
| WBC (×109/L) | 1.9 (0.4-210) | |||
| ≤3.5 | 78 (64) | 71 (91) | ||
| 3.5-10 | 15 (12) | 13 (87) | .02 | |
| 10-50 | 20 (16) | 19 (95) | ||
| >50 | 10 (8) | 6 (60) | ||
| Hemoglobin (g/dL) | 9.3 (4.4-13.1) | |||
| ≤10 | 78 (63) | 68 (87) | NS | |
| >10 | 45 (37) | 41 (91) | ||
| Platelets (×109/L) | 21 (1-161) | |||
| ≤10 | 23 (19) | 18 (78) | ||
| 11-50 | 76 (63) | 69 (91) | NS | |
| >50 | 22 (18) | 21 (95) | ||
| FAB subtype | ||||
| Typical | 100 (81) | 90 (90) | NS | |
| Variant | 23 (19) | 19 (83) | ||
| Cytogenetics (n = 94) | ||||
| Normal | 4 (4) | 4 (100) | ||
| t(15;17) | 68 (72) | 58 (88) | NS | |
| t(15;17), +8 | 10 (11) | 10 (100) | ||
| t(15;17), plus other abnormality | 9 (10) | 9 (100) | ||
| Other | 3 (3) | 3 (100) | ||
| PML/RARα (n = 121) | ||||
| BCR1/BCR2 | 68 (56) | 60 (88) | NS | |
| BCR3 | 53 (44) | 47 (89) |
Abbreviation: NS, not significant.