Presence of Characteristic Translocations in Different Subtypes of BBCL
| Histopathological Lymphoma Subtype According to: . | ||||||
|---|---|---|---|---|---|---|
| Kiel Classification . | cb Lymphoma . | ib Lymphoma . | BL . | Centrocytoid-cb Lymphoma . | Other BBCL . | All . |
| REAL Classification . | Diffuse Large Cell Lymphoma . | BL . | bMCL Variant . | Other High-Grade BCL‡ . | ||
| Aberrant clones | 63 (92.6%) | 26 (92.9%) | 10 (90.9%) | 11 (100%) | 6 (75.0%) | 116 (92.1%) |
| Complex aberrant clones* | 50 (73.5%) | 22 (78.6%) | 2 (18.2%) | 9 (81.8%) | 5 (62.5%) | 88 (69.8%) |
| Chromosome translocations | ||||||
| t(8;14) | 2 (2.9%) | 0 | 6 (54.5%) | 0 | 0 | 8 (6.3%) |
| t(11;14) | 0 | 0 | 0 | 11 (100%) | 0 | 11 (8.7%) |
| t(14;18) | 20 (29.4%) | 1 (3.6%) | 2 (18.2%) | 0 | 0 | 23 (18.3%) |
| t(3;14)† | 9 (12.3%) | 5 (17.9%) | 1 (9.1%) | 0 | 1 (12.5%) | 16 (12.7%) |
| Histopathological Lymphoma Subtype According to: . | ||||||
|---|---|---|---|---|---|---|
| Kiel Classification . | cb Lymphoma . | ib Lymphoma . | BL . | Centrocytoid-cb Lymphoma . | Other BBCL . | All . |
| REAL Classification . | Diffuse Large Cell Lymphoma . | BL . | bMCL Variant . | Other High-Grade BCL‡ . | ||
| Aberrant clones | 63 (92.6%) | 26 (92.9%) | 10 (90.9%) | 11 (100%) | 6 (75.0%) | 116 (92.1%) |
| Complex aberrant clones* | 50 (73.5%) | 22 (78.6%) | 2 (18.2%) | 9 (81.8%) | 5 (62.5%) | 88 (69.8%) |
| Chromosome translocations | ||||||
| t(8;14) | 2 (2.9%) | 0 | 6 (54.5%) | 0 | 0 | 8 (6.3%) |
| t(11;14) | 0 | 0 | 0 | 11 (100%) | 0 | 11 (8.7%) |
| t(14;18) | 20 (29.4%) | 1 (3.6%) | 2 (18.2%) | 0 | 0 | 23 (18.3%) |
| t(3;14)† | 9 (12.3%) | 5 (17.9%) | 1 (9.1%) | 0 | 1 (12.5%) | 16 (12.7%) |
Complex aberrant clones were defined as containing 4 or more abnormalities. Balanced translocations were considered as 1 abnormality.
Including other changes of 3q27, namely t(1;3)(q34;q27), t(2;3)(q35;q27), t(3;12)(q27;q13q24), t(3;22)(q27;q11), inv(3)(q13q27), dup(3)(q21q27), r(3)(p2?q2?7), add(3)(q27).
Including unclassifiable BBCL and rare subtypes.