Proportion of Erythroid Cells Produced From Different Sources of Progenitors Containing Different Types of Hb
| Origin of Erythroblasts . | % HbA+ Erythroid Cells . | % HbF+Erythroid Cells . | ||||
|---|---|---|---|---|---|---|
| Fetal Liver . | Cord Blood . | Adult Marrow . | Fetal Liver . | Cord Blood . | Adult Marrow . | |
| Erythroblasts | 82 ± 14 | 97 ± 3 | 94 | 84 ± 8 | 96 ± 4 | 4 |
| BFU-E/CFU-E | 65 ± 12 | 62 ± 7 | 76 ± 5 | 96 ± 0.2 | 76 ± 13 | 36 ± 8 |
| LTC-IC–derived BFU-E/CFU-E | 84 ± 14 | 76 ± 19 | Not detectable | 92 ± 4 | 88 ± 2 | Not detectable |
| BFU-E/CFU-E from NOD/SCID mice | 63 ± 12 | 61 ± 11 | 55 ± 13 | 87 ± 6 | 38 ± 8 | 20 ± 1 |
| LTC-IC–derived BFU-E/CFU-E from NOD/SCID mice | 66 ± 6 | ND | Not detectable | 71 ± 4 | ND | Not detectable |
| Origin of Erythroblasts . | % HbA+ Erythroid Cells . | % HbF+Erythroid Cells . | ||||
|---|---|---|---|---|---|---|
| Fetal Liver . | Cord Blood . | Adult Marrow . | Fetal Liver . | Cord Blood . | Adult Marrow . | |
| Erythroblasts | 82 ± 14 | 97 ± 3 | 94 | 84 ± 8 | 96 ± 4 | 4 |
| BFU-E/CFU-E | 65 ± 12 | 62 ± 7 | 76 ± 5 | 96 ± 0.2 | 76 ± 13 | 36 ± 8 |
| LTC-IC–derived BFU-E/CFU-E | 84 ± 14 | 76 ± 19 | Not detectable | 92 ± 4 | 88 ± 2 | Not detectable |
| BFU-E/CFU-E from NOD/SCID mice | 63 ± 12 | 61 ± 11 | 55 ± 13 | 87 ± 6 | 38 ± 8 | 20 ± 1 |
| LTC-IC–derived BFU-E/CFU-E from NOD/SCID mice | 66 ± 6 | ND | Not detectable | 71 ± 4 | ND | Not detectable |
Values shown are the percent of the total number of human glycophorin A+ cells that stained positive for the type of Hb being analyzed. Human CFC and LTC-IC from engrafted NOD/SCID mice were assessed 6 weeks posttransplant.
Abbreviation: ND, not done.