Table 2. Total Thrombin, Maximum... | American Society of Hematology

Table 2.

Total Thrombin, Maximum Thrombin Concentration, and Initiation Phase Duration (%) Dependence on Protein Concentration

Protein	Protein Concentration (% of normal)
	50			150
	Total IIa^*	Max.IIa^*	Init.Phase^*	Total IIa^*	Max.IIa^*	Init.Phase^*
Factor V^†	80	77	140	93	93	87
Factor VIII^†	100	77	112	118	152	87
Factor VII^†	106	132	100	98	112	100
Factor IX^†	109	129	75	87	73	112
Factor X^†	82	74	112	93	99	87
Factor XI^†	104	80	100	100	101	100
Factors V, VIII, IX, X^†	41	34	170	90	90	114
Prothrombin
A. 200 μmol/L PCPS
No proteins C, S, and Tm	45	50	100	184	195	100
Proteins C, S, and Tm	50	61	125	171	150	100
B. 2 × 10⁸/mL platelets	41	41	140	221	193	100
AT-III
A. 200 μmol/L PCPS
No proteins C, S, and Tm	204	162	100	74	98	100
Proteins C, S, and Tm	211	136	80	70	71	112
B. 2 × 10⁸/mL platelets	296	262	70	74	90	100
TFPI^†	98	118	67	106	90	117
Protein C^‡	110	90	100	108	93	100
Protein S^‡	93	100	100	101	103	100

Protein	Protein Concentration (% of normal)
	50			150
	Total IIa^*	Max.IIa^*	Init.Phase^*	Total IIa^*	Max.IIa^*	Init.Phase^*
Factor V^†	80	77	140	93	93	87
Factor VIII^†	100	77	112	118	152	87
Factor VII^†	106	132	100	98	112	100
Factor IX^†	109	129	75	87	73	112
Factor X^†	82	74	112	93	99	87
Factor XI^†	104	80	100	100	101	100
Factors V, VIII, IX, X^†	41	34	170	90	90	114
Prothrombin
A. 200 μmol/L PCPS
No proteins C, S, and Tm	45	50	100	184	195	100
Proteins C, S, and Tm	50	61	125	171	150	100
B. 2 × 10⁸/mL platelets	41	41	140	221	193	100
AT-III
A. 200 μmol/L PCPS
No proteins C, S, and Tm	204	162	100	74	98	100
Proteins C, S, and Tm	211	136	80	70	71	112
B. 2 × 10⁸/mL platelets	296	262	70	74	90	100
TFPI^†	98	118	67	106	90	117
Protein C^‡	110	90	100	108	93	100
Protein S^‡	93	100	100	101	103	100

Abbreviations: Max., maximum; Init., initial.

The value achieved in the presence of 100% protein concentration is 100%.

In the absence of protein C, protein S, and Tm.

In the presence of protein C, protein S, and 0.1 nmol/L Tm.