Incidence and Percentage of VH Mutations in Monocytoid B Cells and Other B-Cell Populations
| Type of Cell . | Mutated Cells/ Analyzed Cells . | Percentage of VH Mutation . | References . |
|---|---|---|---|
| Monocytoid B cells | 23/90 (25.6%) | 3.8 | This study |
| Mantle B cells | 0/12 (0%) | 0 | This study |
| 0/9 (0%) | 0 | 46 | |
| Germinal center B cells | 23/25 (92%) | 4.454-150 | This study |
| 20/23 (87%) | 4.94-150 | 46 | |
| Splenic MZB cells IgM+/IgD− | 13/21 (62%) | 3.98 | This study |
| 15/16 (94%) | 4.34-151 | 48 | |
| PP MZB cells IgM+/IgD− | 18/23 (78%) | 5.9‡ | 51 |
| Type of Cell . | Mutated Cells/ Analyzed Cells . | Percentage of VH Mutation . | References . |
|---|---|---|---|
| Monocytoid B cells | 23/90 (25.6%) | 3.8 | This study |
| Mantle B cells | 0/12 (0%) | 0 | This study |
| 0/9 (0%) | 0 | 46 | |
| Germinal center B cells | 23/25 (92%) | 4.454-150 | This study |
| 20/23 (87%) | 4.94-150 | 46 | |
| Splenic MZB cells IgM+/IgD− | 13/21 (62%) | 3.98 | This study |
| 15/16 (94%) | 4.34-151 | 48 | |
| PP MZB cells IgM+/IgD− | 18/23 (78%) | 5.9‡ | 51 |
Abbreviations: MZB cells, marginal zone B cells; PP, Peyer’s patches; VH, variable region of the Ig heavy chain gene.
Displaying intraclonal diversity (ongoing mutations).
Only Ig rearrangements involving VH6 were considered for calculation by the investigators.
Only Ig rearrangements involving VH4.21 were considered for calculation by the investigators.