Ig Isotypes at the Protein and RNA Level of Monocytoid B Cells From 11 Cases of Piringer’s Lymphadenopathy and Other B-Cell Populations
| Markers . | Monocytoid B Cells* . | Mantle Cell* . | GC-B Cells* . | Memory PB-B Cells IgM Only† . | Memory PB-B Cells IgG+† . | Splenic MZB Cells‡ . | Plasma Cells* . | Nodal MZB Cells2-153 . |
|---|---|---|---|---|---|---|---|---|
| Protein | ||||||||
| sIgM | −/+ | + | − | + | − | + | − | + |
| sIgD | −/+ | + | − | − | − | −/+ | − | − |
| sIgG | − | − | − | − | + | − | − | − |
| Cytoplasmic Ig IgG > IgA > IgD2-154 | − | − | + (many) | − | − | − | + | + (some) |
| RNA | ||||||||
| Low Igμ | −/+ | + | −/+ | + | − | NA | − | NA |
| Low Igδ | −/+ | + | − | NA | NA | NA | − | NA |
| Low Igγ | +/− | − | +/− | − | + | NA | − | NA |
| High Ig2-155 | − | − | + (many) | NA | NA | NA | + | NA |
| Markers . | Monocytoid B Cells* . | Mantle Cell* . | GC-B Cells* . | Memory PB-B Cells IgM Only† . | Memory PB-B Cells IgG+† . | Splenic MZB Cells‡ . | Plasma Cells* . | Nodal MZB Cells2-153 . |
|---|---|---|---|---|---|---|---|---|
| Protein | ||||||||
| sIgM | −/+ | + | − | + | − | + | − | + |
| sIgD | −/+ | + | − | − | − | −/+ | − | − |
| sIgG | − | − | − | − | + | − | − | − |
| Cytoplasmic Ig IgG > IgA > IgD2-154 | − | − | + (many) | − | − | − | + | + (some) |
| RNA | ||||||||
| Low Igμ | −/+ | + | −/+ | + | − | NA | − | NA |
| Low Igδ | −/+ | + | − | NA | NA | NA | − | NA |
| Low Igγ | +/− | − | +/− | − | + | NA | − | NA |
| High Ig2-155 | − | − | + (many) | NA | NA | NA | + | NA |
Same legend as in Table 1.
Analyzed in 5 cases of Piringer’s lymphadenopathy.
Data from Klein et al43 45 and own unpublished findings.
Analyzed in 2 normal spleens with prominent marginal zones.
Analyzed in 2 to 5 mesenterial lymph nodes (with prominent marginal zones) from 2 patients.
Cells with cytoplasmic Ig correspond to plasma cells and their precursors.
Cells with high Ig mRNA correspond to plasma cells and their precursors.