Immunophenotype and Cellular Admixtures of Monocytoid B Cells From 11 Cases of Piringer’s Lymphadenopathy in Comparison With Other B-Cell Populations
| Expression of . | Monocytoid B Cells* . | Mantle Cells* . | GC-B Cells* . | Memory-PB B Cells† . | Splenic MZB Cells‡ . | Nodal MZB Cells1-153 . |
|---|---|---|---|---|---|---|
| CD 20 | + | + | ++ | + | + | + |
| CD45RA | + | + | +/− | NA | − | − |
| DBA44 | 10-20% | 80% | − | NA | − | − |
| CD23 | − | +− | −/+ | − | − | − |
| CD10 | − | − | + | − | − | − |
| BCL-6 | − | − | + | − | − | − |
| BCL-2 | − | + | − | + | + | + |
| CD5 | − | −/+ | − | − | − | − |
| CD27 | − | − | − | + | NA | NA |
| CD25 | − | − | − | − | − | − |
| CD103 | − | − | − | − | − | − |
| CD11c | − | − | − | − | − | − |
| Ki-67 | 10-35% | 1-5% | 50-100% | NA | 5-10% | 5-10% |
| FDC | Absent | Present | Present | Absent | Absent | Absent |
| T Cells | Absent or very few | Some | Many | Some | Some | |
| Neutrophils | Many | Absent | Absent | Absent or very few | Absent |
| Expression of . | Monocytoid B Cells* . | Mantle Cells* . | GC-B Cells* . | Memory-PB B Cells† . | Splenic MZB Cells‡ . | Nodal MZB Cells1-153 . |
|---|---|---|---|---|---|---|
| CD 20 | + | + | ++ | + | + | + |
| CD45RA | + | + | +/− | NA | − | − |
| DBA44 | 10-20% | 80% | − | NA | − | − |
| CD23 | − | +− | −/+ | − | − | − |
| CD10 | − | − | + | − | − | − |
| BCL-6 | − | − | + | − | − | − |
| BCL-2 | − | + | − | + | + | + |
| CD5 | − | −/+ | − | − | − | − |
| CD27 | − | − | − | + | NA | NA |
| CD25 | − | − | − | − | − | − |
| CD103 | − | − | − | − | − | − |
| CD11c | − | − | − | − | − | − |
| Ki-67 | 10-35% | 1-5% | 50-100% | NA | 5-10% | 5-10% |
| FDC | Absent | Present | Present | Absent | Absent | Absent |
| T Cells | Absent or very few | Some | Many | Some | Some | |
| Neutrophils | Many | Absent | Absent | Absent or very few | Absent |
Abbreviations: GC, germinal center; PB, peripheral blood; MZB, marginal zone B; FDC, follicular dendritic cells; ++, strongly positive; +, positive; +/−, majority positive; −/+, minority positive; −, negative; NA, not analyzed.
Analyzed in 11 cases of Piringer’s lymphadenopathy.
Data from Klein et al43 and own unpublished findings.
Analyzed in 2 normal spleens with prominent marginal zones.
Analyzed in 2 to 5 mesenterial lymph nodes (with prominent marginal zones) from 2 patients.