Table 2. Marrow Grafts From... | American Society of Hematology

Table 2.

Marrow Grafts From DLA-Identical Littermates After Conditioning With 100 cGy TBI Delivered as a Single Dose at 7 cGy/min

Pretransplant Donor PBMC + CTLA4Ig^*	Recipient No.	Sustained Allograft	Acute or Chronic GVHD	Complete Autologous Recovery	Duration of Mixed Chimerism (wk)^†	Cause of Death
No^‡	n = 6	0/6	—	6/6	3-12	ET
					(median, 10)
Yes	E736	NE	—	NE	>3	Intussusception^2-153
	E406	No	—	Yes	8	ET
	E465	No	—	Yes	20	ET
	E519	Yes	No	—	>70
	E520	Yes	No	—	>70
	E606	Yes	No	—	>48
	E633	Yes	No	—	>46

Pretransplant Donor PBMC + CTLA4Ig^*	Recipient No.	Sustained Allograft	Acute or Chronic GVHD	Complete Autologous Recovery	Duration of Mixed Chimerism (wk)^†	Cause of Death
No^‡	n = 6	0/6	—	6/6	3-12	ET
					(median, 10)
Yes	E736	NE	—	NE	>3	Intussusception^2-153
	E406	No	—	Yes	8	ET
	E465	No	—	Yes	20	ET
	E519	Yes	No	—	>70
	E520	Yes	No	—	>70
	E606	Yes	No	—	>48
	E633	Yes	No	—	>46

NOTE. All recipients were given MMF/CSP* after transplant: MMF 10 mg/kg/twice daily, subcutaneously days 0 to 27; CSP, 15 mg/kg/twice daily, orally days −1 to 35.

Abbreviations: ET, euthanized at completion of the study; NE, not evaluable.

10⁶ PBMC/kg/day IV days −7 to −1; CTLA4Ig, 4 mg/kg/d IV days −7 to −1.

†

Assessed by weekly microsatellite marker studies of PBMC or marrow cells.

‡

Data in these dogs were previously published.3

F2-153

Dog was a mixed chimera at the time of death.

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