Cytokine Levels During the First Rituximab Infusion
| IL-6 (normal range, <25 pg/mL) . | |||
|---|---|---|---|
| Patient . | IL-6 Prior Infusion . | IL-6 90 min Postinfusion . | IL-6 7 hrs Postinfusion . |
| Gr. A No. 1 | 25 | 18 | NE |
| Gr. A No. 2 | 9 | 14 | NE |
| Gr. A No. 3 | 20 | 18 | NE |
| Gr. A No. 4 | 16 | 25 | 16 |
| Gr. A No. 5 | 11 | 16 | NE |
| Gr. B No. 6 | 17 | 53 | 15 |
| Gr. B No. 7 | 20 | 62 | 25 |
| Gr. B No. 8 | NE | NE | NE |
| Gr. B No. 9 | 20 | 244 | 40 |
| Gr. B No. 10 | 17 | 319 | 20 |
| Gr. B No. 11 | 18 | 744 | 18 |
| TNF-α (normal range, <20 pg/mL) | |||
| Patient | TNF-α Prior Infusion | TNF-α 90 min Postinfusion | TNF-α 7 h Postinfusion |
| Gr. A No. 1 | 10 | 18 | NE |
| Gr. A No. 2 | 48 | 106 | NE |
| Gr. A No. 3 | 35 | 34 | NE |
| Gr. A No. 4 | 23 | 184 | 8 |
| Gr. A No. 5 | 35 | 78 | NE |
| Gr. B No. 6 | 17 | 71 | 17 |
| Gr. B No. 7 | 20 | 195 | 28 |
| Gr. B No. 8 | NE | NE | NE |
| Gr. B No. 9 | 25 | 351 | 47 |
| Gr. B No. 10 | 12 | 843 | 42 |
| Gr. B No. 11 | 68 | 741 | 56 |
| IL-6 (normal range, <25 pg/mL) . | |||
|---|---|---|---|
| Patient . | IL-6 Prior Infusion . | IL-6 90 min Postinfusion . | IL-6 7 hrs Postinfusion . |
| Gr. A No. 1 | 25 | 18 | NE |
| Gr. A No. 2 | 9 | 14 | NE |
| Gr. A No. 3 | 20 | 18 | NE |
| Gr. A No. 4 | 16 | 25 | 16 |
| Gr. A No. 5 | 11 | 16 | NE |
| Gr. B No. 6 | 17 | 53 | 15 |
| Gr. B No. 7 | 20 | 62 | 25 |
| Gr. B No. 8 | NE | NE | NE |
| Gr. B No. 9 | 20 | 244 | 40 |
| Gr. B No. 10 | 17 | 319 | 20 |
| Gr. B No. 11 | 18 | 744 | 18 |
| TNF-α (normal range, <20 pg/mL) | |||
| Patient | TNF-α Prior Infusion | TNF-α 90 min Postinfusion | TNF-α 7 h Postinfusion |
| Gr. A No. 1 | 10 | 18 | NE |
| Gr. A No. 2 | 48 | 106 | NE |
| Gr. A No. 3 | 35 | 34 | NE |
| Gr. A No. 4 | 23 | 184 | 8 |
| Gr. A No. 5 | 35 | 78 | NE |
| Gr. B No. 6 | 17 | 71 | 17 |
| Gr. B No. 7 | 20 | 195 | 28 |
| Gr. B No. 8 | NE | NE | NE |
| Gr. B No. 9 | 25 | 351 | 47 |
| Gr. B No. 10 | 12 | 843 | 42 |
| Gr. B No. 11 | 68 | 741 | 56 |
Abbreviation: NE, not evaluable.