Hematologic Data in Mice Treated With L-744,832 at 40 mg/kg
| Genotype* . | Treatment . | Start . | White Blood Cell Count (×103 per μL) . | |||
|---|---|---|---|---|---|---|
| 2 wk . | 4 wk . | 6 wk . | 8 wk . | |||
| Nfl+/+ | None | 7.8 | 11.7 | 11 | 9.5 | 11 |
| Nfl+/+ | None | 6.3 | 7.9 | 6 | 8.7 | 10 |
| Nfl+/+ | L-744,832 | 5.2 | 7.6 | 6.2 | 6.5 | 7 |
| Nfl+/+ | L-744,832 | 12 | 3.1 | 8.2 | 8.3 | 8 |
| Nfl−/− | None | 24.1 | 27.4 | 30.1 | 26.8 | 25 |
| Nfl−/− | None | 40.8 | 34.4 | 40.9 | 51.9 | 40 |
| Nfl−/− | L-744,832 | 30.6 | 50.6 | 45 | 36 | 42 |
| Nfl−/− | L-744,832 | 46.6 | 23.2 | 55.6 | 35 | ND |
| Genotype* . | Treatment . | Start . | White Blood Cell Count (×103 per μL) . | |||
|---|---|---|---|---|---|---|
| 2 wk . | 4 wk . | 6 wk . | 8 wk . | |||
| Nfl+/+ | None | 7.8 | 11.7 | 11 | 9.5 | 11 |
| Nfl+/+ | None | 6.3 | 7.9 | 6 | 8.7 | 10 |
| Nfl+/+ | L-744,832 | 5.2 | 7.6 | 6.2 | 6.5 | 7 |
| Nfl+/+ | L-744,832 | 12 | 3.1 | 8.2 | 8.3 | 8 |
| Nfl−/− | None | 24.1 | 27.4 | 30.1 | 26.8 | 25 |
| Nfl−/− | None | 40.8 | 34.4 | 40.9 | 51.9 | 40 |
| Nfl−/− | L-744,832 | 30.6 | 50.6 | 45 | 36 | 42 |
| Nfl−/− | L-744,832 | 46.6 | 23.2 | 55.6 | 35 | ND |
Abbreviation: ND, not determined.
Refers to genotype of transplanted fetal liver cells.