Percent Binding of Monoclonal Antibodies to the Surface of Control and mPEG-Modified PBMC (dosage of mPEG per 4 × 106 PBMC)
| CD Molecule . | Function (cell type found on) . | Control PBMC . | mPEG-Modified PBMC . | |
|---|---|---|---|---|
| 0.6 mMol/L . | 2.4 mmol/L . | |||
| CD2 (LFA-2) | Adhesion molecule (T cell) | 82.3% | 77.3% | 31.6% |
| CD62L (L-selectin) | Adhesion molecule (APC and T cells) | 77.8% | 65.9% | 52.4% |
| CD11a (LFA-1) | Adhesion molecule (APC and T cells) | 94.0% | 82.3% | 43.9% |
| CD58 (LFA-3) | Adhesion molecule (APC and T cells) | 47.6% | 54.2% | 26.5% |
| CD8 | Binds MHC class I (TK cell) | 24.4% | ND | 0.06% |
| HLA class II | Present peptide (APC) | 8.9% | 11.8% | 10.1% |
| CD Molecule . | Function (cell type found on) . | Control PBMC . | mPEG-Modified PBMC . | |
|---|---|---|---|---|
| 0.6 mMol/L . | 2.4 mmol/L . | |||
| CD2 (LFA-2) | Adhesion molecule (T cell) | 82.3% | 77.3% | 31.6% |
| CD62L (L-selectin) | Adhesion molecule (APC and T cells) | 77.8% | 65.9% | 52.4% |
| CD11a (LFA-1) | Adhesion molecule (APC and T cells) | 94.0% | 82.3% | 43.9% |
| CD58 (LFA-3) | Adhesion molecule (APC and T cells) | 47.6% | 54.2% | 26.5% |
| CD8 | Binds MHC class I (TK cell) | 24.4% | ND | 0.06% |
| HLA class II | Present peptide (APC) | 8.9% | 11.8% | 10.1% |
Abbreviation: ND, not determined.