Table 3. Effect of Intravenous AR545C or... | American Society of Hematology

Table 3.

Effect of Intravenous AR545C or S-nitroso-AR545 Injection on Hemostatic Parameters in Rabbits

	Bleeding Time (s)
Time (min)	0	60	120
(normal range)	(58-73)
AR545C	62 ± 2	130 ± 11	90 ± 20
S-nitroso-AR545C	63 ± 5	483 ± 17^3-150	260 ± 10^3-150
	PT (s)
Time (min)	0	60	120
(normal range)	(10.8-11.2)
AR545C	11.0 ± 0.1	10.6 ± 0.2	10.8 ± 0.3
S-nitroso-AR545C	11.0 ± 0.2	10.8 ± 0.1	10.7 ± 0.4
	PTT (s)
Time (min)	0	60	120
AR545C	11.8 ± 0.9^3-151	11.9 ± 0.6^3-151	12.8 ± 0.1^3-151
(normal range)	(10.1-13.3)^3-151
S-nitroso-AR545C	15.5 ± 0.5^3-152	16.5 ± 0.2^3-152	15.2 ± 0.3^3-152
(normal range)	(14.6-16.3)^3-152
	Platelets (×10⁹/L)
Time (min)	0	60	120
(normal range)	(355-468)
AR545C	379 ± 22	403 ± 10	435 ± 12
S-nitroso-AR545C	446 ± 11	400 ± 18	399 ± 17

	Bleeding Time (s)
Time (min)	0	60	120
(normal range)	(58-73)
AR545C	62 ± 2	130 ± 11	90 ± 20
S-nitroso-AR545C	63 ± 5	483 ± 17^3-150	260 ± 10^3-150
	PT (s)
Time (min)	0	60	120
(normal range)	(10.8-11.2)
AR545C	11.0 ± 0.1	10.6 ± 0.2	10.8 ± 0.3
S-nitroso-AR545C	11.0 ± 0.2	10.8 ± 0.1	10.7 ± 0.4
	PTT (s)
Time (min)	0	60	120
AR545C	11.8 ± 0.9^3-151	11.9 ± 0.6^3-151	12.8 ± 0.1^3-151
(normal range)	(10.1-13.3)^3-151
S-nitroso-AR545C	15.5 ± 0.5^3-152	16.5 ± 0.2^3-152	15.2 ± 0.3^3-152
(normal range)	(14.6-16.3)^3-152
	Platelets (×10⁹/L)
Time (min)	0	60	120
(normal range)	(355-468)
AR545C	379 ± 22	403 ± 10	435 ± 12
S-nitroso-AR545C	446 ± 11	400 ± 18	399 ± 17

Results are mean ± SEM values of 3 animals.

P < .001 compared with control (t = 0) or AR545C.

Measured with Thrombosil I or

Actin FS as described in Materials and Methods.