FcγRIII on Mast Cells and TNF Released From Mast Cells Are Responsible for the Pathogenesis of Skin Vasculitis
| FcRγ . | 6-19 . | No. . | BMMC Transfer (SC)3-150 . | Ear Lesions . |
|---|---|---|---|---|
| −/− | + | 8 | FcRγ +/− | 6/8 |
| 4 | FcRγ −/− | 0/4 | ||
| 6 | FcγRIII −/− | 0/6 | ||
| 6 | TNFαβ −/− | 1/6 | ||
| −/− | − | 6 | FcRγ +/− | 0/6 |
| 6 | FcγRIII −/− | 0/6 |
| FcRγ . | 6-19 . | No. . | BMMC Transfer (SC)3-150 . | Ear Lesions . |
|---|---|---|---|---|
| −/− | + | 8 | FcRγ +/− | 6/8 |
| 4 | FcRγ −/− | 0/4 | ||
| 6 | FcγRIII −/− | 0/6 | ||
| 6 | TNFαβ −/− | 1/6 | ||
| −/− | − | 6 | FcRγ +/− | 0/6 |
| 6 | FcγRIII −/− | 0/6 |
Mice were inoculated with 6-19 hybridoma cells as described in Table 1. Seven days later, BMMC were SC transferred into 6-19–treated FcRγ −/− mice.
BMMC were prepared as described in Materials and Methods.