Presenting Clinico-Biological Features of 478 Children With AML and Outcome
| Cytogenetic Subgroup . | No. of Cases (% of population) . | Median Age (yr) . | Sex (M/F) . | Median WBC Count (×109/L) . | Remission Rate (%) . | 4-yr EFS (% ± SE, P Value) . | |
|---|---|---|---|---|---|---|---|
| All patients | 478 (100.0) | 7.8 | 259/219 | 20.1 | 406 (84.9) | 33.8 ± 2.4 | |
| Normal karyotype | 109 (22.8) | 11.3 | 57/52 | 24.5 | 93 (85.3) | 43.1 ± 5.0 | .012 |
| t(8;21)(q22;q22) | 56 (11.7) | 10.7 | 29/27 | 15.9 | 54 (96.4) | 45.1 ± 7.7 | .014 |
| t(15;17)(q21;q12-21) | 55 (11.5) | 12.8 | 32/23 | 8.4 | 41 (74.5) | 19.6 ± 8.0 | .033 |
| inv(16)(p13q22)/t(16;16) | 28 (5.9) | 7.8 | 19/9 | 60.5 | 27 (96.4) | 58.2 ± 10.9 | .0071 |
| 11q23 Abnormalities | 88 (18.4) | 3.0 | 44/44 | 26.7 | 72 (81.8) | 23.8 ± 4.8 | .0013 |
| Monosomy 7 | 9 (1.9) | 10.4 | 7/2 | 20.1 | 6 (66.7) | ||
| Trisomy 8* | 10 (2.1) | 14.9 | 8/2 | 53.7 | 8 (80.0) | ||
| Trisomy 21† | 7 (1.5) | 1.9 | 2/5 | 12.1 | 6 (85.7) | ||
| Rare recurrent translocations | 27 (5.6) | 6.9 | 14/13 | 18.1 | 22 (81.5) | 19.7 ± 8.8 | .086 |
| t(10;11)(p13;q21) | 9 (1.9) | 8.7 | 6/3 | 23.8 | 8 (88.9) | ||
| t(6;9)(p23;q34) | 6 (1.3) | 11.2 | 2/4 | 15.4 | 5 (83.3) | ||
| t(3;5)(q25;q34) | 5 (1.1) | 4.5 | 4/1 | 22.5 | 4 (80.0) | ||
| t(1;22)(p13;q13) | 4 (0.8) | 0.4 | 1/3 | 19.5 | 3 (75.0) | ||
| t(8;16)(p11;p13) | 3 (0.6) | 7.2 | 1/2 | 10.8 | 2 (66.7) | ||
| Miscellaneous | 89 (18.6) | 3.6 | 47/42 | 17.4 | 77 (86.5) | 34.8 ± 5.6 | .85 |
| Single clonal abnormality | 36 (7.5) | 10.5 | 20/16 | 22.4 | 31 (86.1) | 38.9 ± 9.2 | |
| Multiple clonal abnormalities | 53 (11.1) | 2.2 | 27/26 | 13.8 | 46 (86.8) | 32.1 ± 7.1 | |
| Cytogenetic Subgroup . | No. of Cases (% of population) . | Median Age (yr) . | Sex (M/F) . | Median WBC Count (×109/L) . | Remission Rate (%) . | 4-yr EFS (% ± SE, P Value) . | |
|---|---|---|---|---|---|---|---|
| All patients | 478 (100.0) | 7.8 | 259/219 | 20.1 | 406 (84.9) | 33.8 ± 2.4 | |
| Normal karyotype | 109 (22.8) | 11.3 | 57/52 | 24.5 | 93 (85.3) | 43.1 ± 5.0 | .012 |
| t(8;21)(q22;q22) | 56 (11.7) | 10.7 | 29/27 | 15.9 | 54 (96.4) | 45.1 ± 7.7 | .014 |
| t(15;17)(q21;q12-21) | 55 (11.5) | 12.8 | 32/23 | 8.4 | 41 (74.5) | 19.6 ± 8.0 | .033 |
| inv(16)(p13q22)/t(16;16) | 28 (5.9) | 7.8 | 19/9 | 60.5 | 27 (96.4) | 58.2 ± 10.9 | .0071 |
| 11q23 Abnormalities | 88 (18.4) | 3.0 | 44/44 | 26.7 | 72 (81.8) | 23.8 ± 4.8 | .0013 |
| Monosomy 7 | 9 (1.9) | 10.4 | 7/2 | 20.1 | 6 (66.7) | ||
| Trisomy 8* | 10 (2.1) | 14.9 | 8/2 | 53.7 | 8 (80.0) | ||
| Trisomy 21† | 7 (1.5) | 1.9 | 2/5 | 12.1 | 6 (85.7) | ||
| Rare recurrent translocations | 27 (5.6) | 6.9 | 14/13 | 18.1 | 22 (81.5) | 19.7 ± 8.8 | .086 |
| t(10;11)(p13;q21) | 9 (1.9) | 8.7 | 6/3 | 23.8 | 8 (88.9) | ||
| t(6;9)(p23;q34) | 6 (1.3) | 11.2 | 2/4 | 15.4 | 5 (83.3) | ||
| t(3;5)(q25;q34) | 5 (1.1) | 4.5 | 4/1 | 22.5 | 4 (80.0) | ||
| t(1;22)(p13;q13) | 4 (0.8) | 0.4 | 1/3 | 19.5 | 3 (75.0) | ||
| t(8;16)(p11;p13) | 3 (0.6) | 7.2 | 1/2 | 10.8 | 2 (66.7) | ||
| Miscellaneous | 89 (18.6) | 3.6 | 47/42 | 17.4 | 77 (86.5) | 34.8 ± 5.6 | .85 |
| Single clonal abnormality | 36 (7.5) | 10.5 | 20/16 | 22.4 | 31 (86.1) | 38.9 ± 9.2 | |
| Multiple clonal abnormalities | 53 (11.1) | 2.2 | 27/26 | 13.8 | 46 (86.8) | 32.1 ± 7.1 | |