Karyotypic Features in Patients With an Abnormality of Chromosome Arm 9p
| Category . | Percentage of Patients* . | Total N = 201 . | ||||
|---|---|---|---|---|---|---|
| NCI Standard Risk† N = 77 . | NCI Poor Risk† N = 124 . | |||||
| N . | (%) . | N . | (%) . | N . | (%) . | |
| 9p Abnormality | ||||||
| Balanced translocation | 8 | (10) | 18 | (15) | 26 | (13) |
| Dicentric chromosome 9 | 22 | (29) | 17 | (14) | 39 | (19) |
| dic(9;20)‡ | 12 | (16) | 6 | (5) | 18 | (9) |
| dic(9;12) | 5 | (8) | 7 | (6) | 12 | (6) |
| dic(7;9) | 2 | (3) | 2 | (2) | 4 | (3) |
| other | 3 | (4) | 2 | (2) | 5 | (2) |
| i(9)(q10) | 5 | (6) | 14 | (11) | 19 | (10) |
| del(9p) | 27 | (35) | 60 | (48) | 87 | (43) |
| add/der(9p) | 17 | (22) | 24 | (19) | 41 | (20) |
| Ploidy group2-153 | ||||||
| Hypodiploid (<46) | 20 | (26) | 35 | (28) | 55 | (27) |
| Pseudodiploid | 33 | (43) | 71 | (57) | 104 | (52) |
| Hyperdiploid (47-50) | 16 | (21) | 13 | (10) | 29 | (14) |
| Hyperdiploid (>50) | 8 | (10) | 5 | (4) | 13 | (7) |
| Additional abnormality | ||||||
| t(1;19)(q23;p13) or der(19)t(1;19)(q23; p13)2-155 | 3 | (4) | 10 | (8) | 13 | (6.5) |
| del(6q) | 7 | (9) | 15 | (12) | 22 | (11.0) |
| Abnormal 12p | 13 | (17) | 20 | (26) | 33 | (16.4) |
| t(9;22)(q34;q11) | 3 | (4) | 15 | (12) | 18 | (8.5) |
| Category . | Percentage of Patients* . | Total N = 201 . | ||||
|---|---|---|---|---|---|---|
| NCI Standard Risk† N = 77 . | NCI Poor Risk† N = 124 . | |||||
| N . | (%) . | N . | (%) . | N . | (%) . | |
| 9p Abnormality | ||||||
| Balanced translocation | 8 | (10) | 18 | (15) | 26 | (13) |
| Dicentric chromosome 9 | 22 | (29) | 17 | (14) | 39 | (19) |
| dic(9;20)‡ | 12 | (16) | 6 | (5) | 18 | (9) |
| dic(9;12) | 5 | (8) | 7 | (6) | 12 | (6) |
| dic(7;9) | 2 | (3) | 2 | (2) | 4 | (3) |
| other | 3 | (4) | 2 | (2) | 5 | (2) |
| i(9)(q10) | 5 | (6) | 14 | (11) | 19 | (10) |
| del(9p) | 27 | (35) | 60 | (48) | 87 | (43) |
| add/der(9p) | 17 | (22) | 24 | (19) | 41 | (20) |
| Ploidy group2-153 | ||||||
| Hypodiploid (<46) | 20 | (26) | 35 | (28) | 55 | (27) |
| Pseudodiploid | 33 | (43) | 71 | (57) | 104 | (52) |
| Hyperdiploid (47-50) | 16 | (21) | 13 | (10) | 29 | (14) |
| Hyperdiploid (>50) | 8 | (10) | 5 | (4) | 13 | (7) |
| Additional abnormality | ||||||
| t(1;19)(q23;p13) or der(19)t(1;19)(q23; p13)2-155 | 3 | (4) | 10 | (8) | 13 | (6.5) |
| del(6q) | 7 | (9) | 15 | (12) | 22 | (11.0) |
| Abnormal 12p | 13 | (17) | 20 | (26) | 33 | (16.4) |
| t(9;22)(q34;q11) | 3 | (4) | 15 | (12) | 18 | (8.5) |
Percentage of patients within each risk group; most patients had multiple abnormalities and some patients had more than 1 abnormality of chromosome arm 9p.
NCI standard risk = 1 to 9 years with WBC <50,000/μL; NCI poor risk = age ≥10 years or WBC ≥50,000/μL.6
Abbreviations: del, deletion; add, additional chromosomal material of unknown origin; der, derivative; dic, dicentric; i, isochromosome; t, translocation.
Based on simplest clone.
Standard risk, all 3 cases had an unbalanced translocation; poor risk, 7 cases had an unbalanced, and 3 cases had a balanced translocation.