Presenting Features of Children With ALL and Abnormalities of Chromosome Arm 9p
| Variable . | Category . | Patients With Abnormal 9p (N = 201) . | Patients With Normal 9p (N = 1,638) . | P Value* . | ||
|---|---|---|---|---|---|---|
| No. . | (%) . | No. . | (%) . | |||
| Age (yr) | 1-9 | 112 | (56) | 1,248 | (76) | <.0001 |
| ≥10 | 89 | (44) | 390 | (24) | ||
| WBC | <20 | 99 | (49) | 1,043 | (64) | .0002 |
| (×109/L) | 20-49 | 36 | (18) | 240 | (15) | |
| ≥50 | 66 | (33) | 355 | (22) | ||
| Sex | Male | 108 | (54) | 911 | (56) | .61 |
| Female | 93 | (46) | 727 | (44) | ||
| Race | White | 167 | (83) | 1,325 | (81) | .22 |
| Black | 15 | (8) | 95 | (6) | ||
| Other | 19 | (10) | 218 | (13) | ||
| Down | Yes | 3 | (1) | 33 | (2) | .61 |
| syndrome | No | 198 | (99) | 1,605 | (98) | |
| Liver | Normal | 98 | (48) | 811 | (50) | .85 |
| Mod enlarged† | 97 | (48) | 761 | (47) | ||
| Markedly enlarged | 6 | (3) | 59 | (4) | ||
| Spleen | Normal | 73 | (36) | 807 | (49) | .002 |
| Mod enlarged | 112 | (56) | 732 | (45) | ||
| Markedly enlarged | 16 | (8) | 98 | (6) | ||
| Lymph nodes | Normal | 97 | (48) | 834 | (51) | .69 |
| Mod enlarged | 88 | (44) | 694 | (42) | ||
| Markedly enlarged | 16 | (8) | 110 | (7) | ||
| Mediastinal | Absent | 183 | (91) | 1,487 | (91) | .15 |
| mass | Small | 5 | (3) | 79 | (5) | |
| Large | 13 | (7) | 72 | (4) | ||
| Hemoglobin | 1-7.9 | 97 | (48) | 869 | (53) | .01 |
| (g/dL) | 8.0-10.9 | 63 | (31) | 559 | (34) | |
| ≥11.0 | 41 | (20) | 210 | (13) | ||
| Platelets | 1-49 | 100 | (50) | 757 | (46) | .39 |
| (×109/L) | 50-149 | 62 | (31) | 494 | (30) | |
| ≥150 | 39 | (19) | 387 | (24) | ||
| CNS disease | Yes | 8 | (4) | 44 | (3) | .30 |
| at diagnosis | No | 192 | (96) | 1,577 | (97) | |
| Immuno | B-lineage | 102 | (83) | 762 | (81) | .65 |
| phenotype | T-lineage | 21 | (17) | 176 | (19) | |
| NCI risk group | Standard | 71 | (35) | 1,003 | (61) | <.0001 |
| Poor | 130 | (65) | 635 | (39) | ||
| Ploidy group‡ | Normal | 0 | (0) | 564 | (34) | <.0001 |
| Hypodiploid | 55 | (27) | 52 | (3) | ||
| Pseudodiploid | 104 | (52) | 383 | (23) | ||
| Hyperdiploid (47-50) | 29 | (14) | 168 | (10) | ||
| Hyperdiploid (>50) | 13 | (6) | 471 | (29) | ||
| Variable . | Category . | Patients With Abnormal 9p (N = 201) . | Patients With Normal 9p (N = 1,638) . | P Value* . | ||
|---|---|---|---|---|---|---|
| No. . | (%) . | No. . | (%) . | |||
| Age (yr) | 1-9 | 112 | (56) | 1,248 | (76) | <.0001 |
| ≥10 | 89 | (44) | 390 | (24) | ||
| WBC | <20 | 99 | (49) | 1,043 | (64) | .0002 |
| (×109/L) | 20-49 | 36 | (18) | 240 | (15) | |
| ≥50 | 66 | (33) | 355 | (22) | ||
| Sex | Male | 108 | (54) | 911 | (56) | .61 |
| Female | 93 | (46) | 727 | (44) | ||
| Race | White | 167 | (83) | 1,325 | (81) | .22 |
| Black | 15 | (8) | 95 | (6) | ||
| Other | 19 | (10) | 218 | (13) | ||
| Down | Yes | 3 | (1) | 33 | (2) | .61 |
| syndrome | No | 198 | (99) | 1,605 | (98) | |
| Liver | Normal | 98 | (48) | 811 | (50) | .85 |
| Mod enlarged† | 97 | (48) | 761 | (47) | ||
| Markedly enlarged | 6 | (3) | 59 | (4) | ||
| Spleen | Normal | 73 | (36) | 807 | (49) | .002 |
| Mod enlarged | 112 | (56) | 732 | (45) | ||
| Markedly enlarged | 16 | (8) | 98 | (6) | ||
| Lymph nodes | Normal | 97 | (48) | 834 | (51) | .69 |
| Mod enlarged | 88 | (44) | 694 | (42) | ||
| Markedly enlarged | 16 | (8) | 110 | (7) | ||
| Mediastinal | Absent | 183 | (91) | 1,487 | (91) | .15 |
| mass | Small | 5 | (3) | 79 | (5) | |
| Large | 13 | (7) | 72 | (4) | ||
| Hemoglobin | 1-7.9 | 97 | (48) | 869 | (53) | .01 |
| (g/dL) | 8.0-10.9 | 63 | (31) | 559 | (34) | |
| ≥11.0 | 41 | (20) | 210 | (13) | ||
| Platelets | 1-49 | 100 | (50) | 757 | (46) | .39 |
| (×109/L) | 50-149 | 62 | (31) | 494 | (30) | |
| ≥150 | 39 | (19) | 387 | (24) | ||
| CNS disease | Yes | 8 | (4) | 44 | (3) | .30 |
| at diagnosis | No | 192 | (96) | 1,577 | (97) | |
| Immuno | B-lineage | 102 | (83) | 762 | (81) | .65 |
| phenotype | T-lineage | 21 | (17) | 176 | (19) | |
| NCI risk group | Standard | 71 | (35) | 1,003 | (61) | <.0001 |
| Poor | 130 | (65) | 635 | (39) | ||
| Ploidy group‡ | Normal | 0 | (0) | 564 | (34) | <.0001 |
| Hypodiploid | 55 | (27) | 52 | (3) | ||
| Pseudodiploid | 104 | (52) | 383 | (23) | ||
| Hyperdiploid (47-50) | 29 | (14) | 168 | (10) | ||
| Hyperdiploid (>50) | 13 | (6) | 471 | (29) | ||