Comparison of the Phase I/II Hematologic Values of Children and Adults With Sickle Cell Anemia Who Were Receiving Treatment at the End of Their Respective Studies
| Variable . | HUG-KIDS (mean Δ) n = 665-150 . | Adult Phase I/II Trial (mean Δ) n = 325-151 . |
|---|---|---|
| Hb (g/dL) | 1.2 | 1.2 |
| MCV (fL) | 14 | 23 |
| ARC (×109/L) | −146 | −158 |
| WBC (×109/L) | −4.2 | −5.0 |
| ANC (×109/L) | −2.2 | −2.8 |
| Platelets (×109/L) | −108 | −83 |
| Total bilirubin (mg/dL) | −1.0 | −2.0 |
| Hb F (%) | 9.6 | 11.2 |
| F cells (%) | 31 | 45 |
| Variable . | HUG-KIDS (mean Δ) n = 665-150 . | Adult Phase I/II Trial (mean Δ) n = 325-151 . |
|---|---|---|
| Hb (g/dL) | 1.2 | 1.2 |
| MCV (fL) | 14 | 23 |
| ARC (×109/L) | −146 | −158 |
| WBC (×109/L) | −4.2 | −5.0 |
| ANC (×109/L) | −2.2 | −2.8 |
| Platelets (×109/L) | −108 | −83 |
| Total bilirubin (mg/dL) | −1.0 | −2.0 |
| Hb F (%) | 9.6 | 11.2 |
| F cells (%) | 31 | 45 |