Laboratory Parameters (mean ± standard deviation) During HU Therapy
| Variable . | Entry . | 6 mo . | 12 mo . | 18 mo . | 24 mo . |
|---|---|---|---|---|---|
| No. of patients | 84 | 78 | 77 | 71 | 35 |
| Hematology | |||||
| Hb (g/dL) | 7.8 ± 1.0 | 8.8 ± 1.0 | 9.0 ± 1.4 | 9.1 ± 1.3 | 9.0 ± 1.1 |
| MCV (fL) | 85.9 ± 6.6 | 99.5 ± 9.0 | 101.3 ± 10.2 | 101.7 ± 10.5 | 98.9 ± 9.1 |
| MCH (pg) | 29.5 ± 2.8 | 34.1 ± 3.4 | 34.6 ± 3.6 | 34.5 ± 3.8 | 33.9 ± 3.1 |
| MCHC (g/dL) | 34.3 ± 1.6 | 34.2 ± 1.1 | 34.2 ± 1.4 | 34.0 ± 1.0 | 34.3 ± 1.5 |
| ARC (×109/L) | 354 ± 144 | 204 ± 83 | 191 ± 100 | 200 ± 82 | 215 ± 92 |
| WBC (×109/L) | 13.6 ± 3.9 | 9.3 ± 3.0 | 9.2 ± 3.2 | 9.1 ± 3.1 | 9.2 ± 3.0 |
| ANC (×109/L) | 7.0 ± 3.0 | 4.4 ± 2.1 | 4.4 ± 2.2 | 4.4 ± 2.6 | 4.6 ± 2.3 |
| PLT (×109/L) | 461 ± 157 | 371 ± 130 | 371 ± 153 | 357 ± 144 | 357 ± 122 |
| Serum chemistries | |||||
| Total bilirubin (mg/dL) | 3.6 ± 2.6 | 2.9 ± 2.1 | 2.5 ± 2.0 | 2.5 ± 1.8 | 2.8 ± 2.5 |
| LDH (IU/L) | 1,126 ± 699 | 921 ± 592 | 807 ± 520 | 858 ± 490 | 973 ± 500 |
| ALT (IU/L) | 27 ± 14 | 28 ± 20 | 28 ± 22 | 26 ± 13 | 27 ± 12 |
| Creatinine (mg/dL) | 0.4 ± 0.2 | 0.4 ± 0.2 | 0.4 ± 0.2 | 0.4 ± 0.2 | 0.4 ± 0.1 |
| Hb F parameters | |||||
| Hb F (%) | 7.3 ± 4.9 | 14.9 ± 6.4 | 17.8 ± 7.2 | 16.3 ± 7.2 | 15.5 ± 7.3 |
| (N = 69) | (N = 70) | (N = 69) | (N = 62) | (N = 31) | |
| F cells (%) | 34.6 ± 17.8 | 59.2 ± 18.6 | 66.5 ± 19.6 | 62.9 ± 18.1 | 62.2 ± 18.1 |
| (N = 72) | (N = 72) | (N = 68) | (N = 66) | (N = 33) |
| Variable . | Entry . | 6 mo . | 12 mo . | 18 mo . | 24 mo . |
|---|---|---|---|---|---|
| No. of patients | 84 | 78 | 77 | 71 | 35 |
| Hematology | |||||
| Hb (g/dL) | 7.8 ± 1.0 | 8.8 ± 1.0 | 9.0 ± 1.4 | 9.1 ± 1.3 | 9.0 ± 1.1 |
| MCV (fL) | 85.9 ± 6.6 | 99.5 ± 9.0 | 101.3 ± 10.2 | 101.7 ± 10.5 | 98.9 ± 9.1 |
| MCH (pg) | 29.5 ± 2.8 | 34.1 ± 3.4 | 34.6 ± 3.6 | 34.5 ± 3.8 | 33.9 ± 3.1 |
| MCHC (g/dL) | 34.3 ± 1.6 | 34.2 ± 1.1 | 34.2 ± 1.4 | 34.0 ± 1.0 | 34.3 ± 1.5 |
| ARC (×109/L) | 354 ± 144 | 204 ± 83 | 191 ± 100 | 200 ± 82 | 215 ± 92 |
| WBC (×109/L) | 13.6 ± 3.9 | 9.3 ± 3.0 | 9.2 ± 3.2 | 9.1 ± 3.1 | 9.2 ± 3.0 |
| ANC (×109/L) | 7.0 ± 3.0 | 4.4 ± 2.1 | 4.4 ± 2.2 | 4.4 ± 2.6 | 4.6 ± 2.3 |
| PLT (×109/L) | 461 ± 157 | 371 ± 130 | 371 ± 153 | 357 ± 144 | 357 ± 122 |
| Serum chemistries | |||||
| Total bilirubin (mg/dL) | 3.6 ± 2.6 | 2.9 ± 2.1 | 2.5 ± 2.0 | 2.5 ± 1.8 | 2.8 ± 2.5 |
| LDH (IU/L) | 1,126 ± 699 | 921 ± 592 | 807 ± 520 | 858 ± 490 | 973 ± 500 |
| ALT (IU/L) | 27 ± 14 | 28 ± 20 | 28 ± 22 | 26 ± 13 | 27 ± 12 |
| Creatinine (mg/dL) | 0.4 ± 0.2 | 0.4 ± 0.2 | 0.4 ± 0.2 | 0.4 ± 0.2 | 0.4 ± 0.1 |
| Hb F parameters | |||||
| Hb F (%) | 7.3 ± 4.9 | 14.9 ± 6.4 | 17.8 ± 7.2 | 16.3 ± 7.2 | 15.5 ± 7.3 |
| (N = 69) | (N = 70) | (N = 69) | (N = 62) | (N = 31) | |
| F cells (%) | 34.6 ± 17.8 | 59.2 ± 18.6 | 66.5 ± 19.6 | 62.9 ± 18.1 | 62.2 ± 18.1 |
| (N = 72) | (N = 72) | (N = 68) | (N = 66) | (N = 33) |
All values at 6 months, except MCHC, ALT, and creatinine are significantly different from baseline (P < .0001). At 12 months, MCV, MCH, LDH, and total bilirubin are significantly different compared with 6 months (P < .05) and the Hb F and F cells are significantly different at the level of P < .05. All other 12-month values are not significantly different than their corresponding 6-month values.