Addition of MCP-1(9-76) to Previously Activated LTC of Normal Hematopoietic Cells Prevents Their Return to a Quiescent State 4 to 5 Days Later
Addition
.
% Kill After3H-thymidine
.
Primitive BFU-E
.
Primitive CFU-GM
.
None
4 ± 5
0 ± 3
MCP-1(9-76)
38 ± 5
35 ± 3
Addition
.
% Kill After3H-thymidine
.
Primitive BFU-E
.
Primitive CFU-GM
.
None
4 ± 5
0 ± 3
MCP-1(9-76)
38 ± 5
35 ± 3
MCP-1(9-76) at 300 ng/mL. Results shown are the mean ± SEM of data obtained in 6 independent experiments. The effect of MCP-1 (9-76) is highly significant (P < .001).