The Ability of MCP-1 to Inhibit the Proliferation of Normal Hematopoietic Cells in Activated LTC Is Blocked by the Addition of MCP-1(9-76)
| Treatment . | % Kill After3H-thymidine . | |
|---|---|---|
| Primitive BFU-E . | Primitive CFU-GM . | |
| MCP-1 | 12 ± 4 | 0 ± 5 |
| None | 52 ± 4 | 50 ± 4 |
| MCP-1(9-76) | 37 ± 2 | 36 ± 13 |
| MCP-1 + MCP-1(9-76) | 52 ± 8 | 51 ± 9 |
| Treatment . | % Kill After3H-thymidine . | |
|---|---|---|
| Primitive BFU-E . | Primitive CFU-GM . | |
| MCP-1 | 12 ± 4 | 0 ± 5 |
| None | 52 ± 4 | 50 ± 4 |
| MCP-1(9-76) | 37 ± 2 | 36 ± 13 |
| MCP-1 + MCP-1(9-76) | 52 ± 8 | 51 ± 9 |
MCP-1 at 100 ng/mL and MCP-1(9-76) at 300 ng/mL. Results shown are the mean ± SEM of data obtained in 5 independent experiments. MCP-1 had a highly significant effect compared with no addition (P < .001), and no effect was seen with the addition of MCP-1(9-76) alone. A significant difference between MCP-1 and MCP-1 + MCP-1 (9-76) was also observed (P < .01).