Table 4.

Phenotypes in Deficiencies of Selectins and Selectin Ligands

LAD II E/P-Deficient Fuc-TVII–Deficient C2 GlcNAcT-Deficient
Developmental defects  Marked  Absent Absent  Absent  
Neutrophilia  Marked  Marked Moderate  Moderate  
Periodontitis  Marked  Present Absent  Absent  
Dermal ulcerations  Absent  Present Absent  Absent  
Hypergammaglobulinemia  Absent  Present NR  NR  
Lymphadenopathy  Absent  Present  Absent Absent  
Rolling defect  Marked  Marked  Marked Moderate  
Peritoneal emigration of neutrophils  Unknown Marked reduction  Marked reduction  Marked reduction 
Lymphocyte homing  Unknown  NR  Marked reduction Normal 
LAD II E/P-Deficient Fuc-TVII–Deficient C2 GlcNAcT-Deficient
Developmental defects  Marked  Absent Absent  Absent  
Neutrophilia  Marked  Marked Moderate  Moderate  
Periodontitis  Marked  Present Absent  Absent  
Dermal ulcerations  Absent  Present Absent  Absent  
Hypergammaglobulinemia  Absent  Present NR  NR  
Lymphadenopathy  Absent  Present  Absent Absent  
Rolling defect  Marked  Marked  Marked Moderate  
Peritoneal emigration of neutrophils  Unknown Marked reduction  Marked reduction  Marked reduction 
Lymphocyte homing  Unknown  NR  Marked reduction Normal 

Abbreviation: NR, not reported.

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