Phenotypes in Deficiencies of β2-Integrins and IgSF Ligands
| . | LAD I . | CD18- Deficient . | CD11b- Deficient . | CD11a- Deficient . | ICAM-1– Deficient . | ICAM-2– Deficient . |
|---|---|---|---|---|---|---|
| Spontaneous infections | Marked | Moderate-marked | None | None | None | None |
| Neutrophilia | Marked | Marked | Minimal | Minimal | Moderate | None |
| Neutrophil migration to | ||||||
| Skin | Absent | Absent | NR | NR | NR | NR |
| Lung | Present | Present | NR | NR | Present | NR |
| Peritoneum | Absent | Present | Present | Reduced | Reduced | NR |
| . | LAD I . | CD18- Deficient . | CD11b- Deficient . | CD11a- Deficient . | ICAM-1– Deficient . | ICAM-2– Deficient . |
|---|---|---|---|---|---|---|
| Spontaneous infections | Marked | Moderate-marked | None | None | None | None |
| Neutrophilia | Marked | Marked | Minimal | Minimal | Moderate | None |
| Neutrophil migration to | ||||||
| Skin | Absent | Absent | NR | NR | NR | NR |
| Lung | Present | Present | NR | NR | Present | NR |
| Peritoneum | Absent | Present | Present | Reduced | Reduced | NR |
Abbreviation: NR, not reported.