Expression Patterns of ALK and NPM in 59 ALK-Positive Lymphomas
| Cases No. . | Pattern of ALK Expression* . | Pattern of NPM Expression* . | Presence of NPM-ALK Gene . | ||
|---|---|---|---|---|---|
| N-Terminus . | C-Terminus . | RT-PCR . | FISH . | ||
| 1-42 | Nuclear and cytoplasmic | Nuclear and cytoplasmic | Nuclear | 16/16 | No data |
| 43, 44 | Cytoplasmic | Nuclear and cytoplasmic | Nuclear | 2/2 | No data |
| 45-59 | Cytoplasmic | Nuclear | Nuclear | 0/8† | 0/2‡ |
| Cases No. . | Pattern of ALK Expression* . | Pattern of NPM Expression* . | Presence of NPM-ALK Gene . | ||
|---|---|---|---|---|---|
| N-Terminus . | C-Terminus . | RT-PCR . | FISH . | ||
| 1-42 | Nuclear and cytoplasmic | Nuclear and cytoplasmic | Nuclear | 16/16 | No data |
| 43, 44 | Cytoplasmic | Nuclear and cytoplasmic | Nuclear | 2/2 | No data |
| 45-59 | Cytoplasmic | Nuclear | Nuclear | 0/8† | 0/2‡ |
All cases were of T or null phenotype.
Refers to the large anaplastic tumor cells present in each case. For interpretation of immunostaining results in cases no. 37 through 42 (lymphohistiocytic or small-cell ALK-positive lymphomas), see Results.
Two cases were associated with t(1;2) (q21;p23) and 1 case with t(2;3) (p23;q21).
Refers to 2 cases with inv(2) (see Wlodarska et al30).