Inhibition of PDTC-Induced Apoptosis by Other Caspases Inhibitors
| PDTC . | YVAD-CHO . | IETD-FMK . | JPX-9 (%) . |
|---|---|---|---|
| (−) | (−) | (−) | 4.0 ± 0.3 |
| (+) | (−) | (−) | 55.5 ± 4.6 |
| (+) | (+) | (−) | 48.9 ± 4.8 |
| (+) | (−) | (+) | 7.0 ± 0.64-150 |
| PDTC . | YVAD-CHO . | IETD-FMK . | JPX-9 (%) . |
|---|---|---|---|
| (−) | (−) | (−) | 4.0 ± 0.3 |
| (+) | (−) | (−) | 55.5 ± 4.6 |
| (+) | (+) | (−) | 48.9 ± 4.8 |
| (+) | (−) | (+) | 7.0 ± 0.64-150 |
JPX-9 cells were cultured with or without PDTC, in the presence or absence of caspases inhibitors, for 24 hours. After incubation, the percentage of cells with hypodiploid DNA was examined by flow cytometry.
P < .01 compared with data without the inhibitor in the presence of PDTC. Data are mean ± SD of 4 experiments.