Structure of the TCR Transcripts at the V-D and D-J Junctions in Patients With OS and in Controls
| . | a . | . | b . | c . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CDR3 Length . | Complete V . | Complete J . | Palindromes . | ||||||||
| Group | A | B | C | D | Group | A | B | A | B | A | B |
| Mean* | 9.06 | 10.44 | 9.42 | 10.16 | No. | 5.0 | 6.0 | 4.0 | 10.0 | 2.0 | 8.0 |
| SD | 1.61 | 2.15 | 1.93 | 1.79 | % | 20.0 | 5.2 | 16.0 | 8.7 | 13.3 | 6.9 |
| P | .068 | .008 | P | .012 | .269 | .854 | |||||
| . | a . | . | b . | c . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CDR3 Length . | Complete V . | Complete J . | Palindromes . | ||||||||
| Group | A | B | C | D | Group | A | B | A | B | A | B |
| Mean* | 9.06 | 10.44 | 9.42 | 10.16 | No. | 5.0 | 6.0 | 4.0 | 10.0 | 2.0 | 8.0 |
| SD | 1.61 | 2.15 | 1.93 | 1.79 | % | 20.0 | 5.2 | 16.0 | 8.7 | 13.3 | 6.9 |
| P | .068 | .008 | P | .012 | .269 | .854 | |||||
| . | d . | e . | f . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N (V-D) . | N (D-J) . | D Length . | Nibbling V . | Nibbling J . | ||||||
| Group | E | F | E | F | E | F | A | B | A | B |
| Mean† | 3.45 | 4.10 | 4.25 | 5.09 | 6.75 | 6.11 | 3.48 | 4.48 | 4.00 | 4.16 |
| SD | 3.85 | 3.63 | 3.73 | 4.62 | 2.53 | 2.00 | 2.76 | 2.55 | 2.57 | 2.97 |
| P | .47 | .448 | .218 | .082 | .803 | |||||
| . | d . | e . | f . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N (V-D) . | N (D-J) . | D Length . | Nibbling V . | Nibbling J . | ||||||
| Group | E | F | E | F | E | F | A | B | A | B |
| Mean† | 3.45 | 4.10 | 4.25 | 5.09 | 6.75 | 6.11 | 3.48 | 4.48 | 4.00 | 4.16 |
| SD | 3.85 | 3.63 | 3.73 | 4.62 | 2.53 | 2.00 | 2.76 | 2.55 | 2.57 | 2.97 |
| P | .47 | .448 | .218 | .082 | .803 | |||||
Groups and number of sequences analyzed are as follows: A, sequences of OS patients obtained in our laboratories (this work and Villa et al16), 25; B, sequences of age-matched children, 115; C, sequences of OS patients (only PBL, this work and previous studies13-16), 91; D, sequences of age-matched children (only PBL), 91; E, sequences of group A in which the TCRD region can be assigned, 20; and F, sequences of group B in which the TCRD region can be assigned, 94.
Mean of amino acids.
Mean of nucleotides.