Characteristics of the Twenty Sequenced Genes
Patients . | VH Family . | Germinal Counterpart . | Homology % . | FR Mutation . | RS . | CDR Mutation . | RS . | CDR/FR . | D . | JH . |
---|---|---|---|---|---|---|---|---|---|---|
CLL-1A | VH5 | V5-a | 98.3 | 3 | 0.5 | 2 | 0 | 1.5 | 2-15 | JH5b |
CLL-1B | VH3 | V3-15 | 100 | 0 | 0 | 0 | 0 | 0 | 3-09 | JH4b |
CLL-2A | VH6 | V6-01 | 95.4 | 11 | 0.8 | 3 | 2 | 0.27 | 2-15 | JH4d |
CLL-2B | VH3 | V3-73 | 90.3 | 16 | 2.2 | 13 | 3.3 | 0.81 | 2-02 | JH6b |
CLL-3A | VH3 | V3-21 | 93.3 | 11 | 1.2 | 9 | 2 | 0.82 | 2-21 | JH4b |
CLL-3B | VH3 | V3-23 | 93.3 | 14 | 2.5 | 6 | 2 | 0.43 | 3-22 | JH4b |
CLL-4A | VH5 | V5-51 | 92.2 | 17 | 2.4 | 6 | 5 | 0.35 | ND | JH5b |
CLL-4B | VH4 | V4-34 | 96.9 | 5 | 4 | 4 | >4 | 0.8 | 5-05 | JH6b |
CLL-5A | VH1 | V1-02 | 90.1 | 21 | 1.33 | 8 | 3 | 0.38 | 2-21 | JH4b |
CLL-5B | VH4 | V4-34 | 94.8 | 13 | 2.25 | 2 | >2 | 0.15 | 2-21 | JH4b |
CLL-6A | VH3 | V3-23 | 90.8 | 22 | 0.83 | 5 | 4 | 0.22 | 6-19 | JH4b |
CLL-6B | VH1 | V1-18 | 93.2 | 16 | 3 | 4 | 1 | 0.25 | ND | JH4b |
CLL-7A | VH3 | V3-13 | 99.0 | 2 | 1 | 1 | >1 | 0.5 | 2-15 | JH4b |
CLL-7B | VH4 | V4-34 | 92.4 | 16 | 0.78 | 6 | 1 | 0.37 | 3-22 | JH4b |
CLL-8A | VH3 | V3-23 | 93.2 | 12 | 0.71 | 8 | >8 | 0.67 | 3-03 | JH4b |
CLL-8B | VH3 | V3-30.3 | 98.3 | 5 | 0.67 | 0 | 0 | 0 | 2-02 | JH4b |
CLL-13A | VH4 | V4-39 | 95.6 | 10 | 4 | 3 | >3 | 0.3 | 6-19 | JH4a |
CLL-13B | VH3 | ND | ND | JH5a | ||||||
CLL-14A | VH4 | ND | 2-02 | JH4a | ||||||
CLL-14B | VH4 | V4-59 | 94.8 | 10 | 1 | 5 | 0.6 | 0.5 | 3-22 | JH1 |
Patients . | VH Family . | Germinal Counterpart . | Homology % . | FR Mutation . | RS . | CDR Mutation . | RS . | CDR/FR . | D . | JH . |
---|---|---|---|---|---|---|---|---|---|---|
CLL-1A | VH5 | V5-a | 98.3 | 3 | 0.5 | 2 | 0 | 1.5 | 2-15 | JH5b |
CLL-1B | VH3 | V3-15 | 100 | 0 | 0 | 0 | 0 | 0 | 3-09 | JH4b |
CLL-2A | VH6 | V6-01 | 95.4 | 11 | 0.8 | 3 | 2 | 0.27 | 2-15 | JH4d |
CLL-2B | VH3 | V3-73 | 90.3 | 16 | 2.2 | 13 | 3.3 | 0.81 | 2-02 | JH6b |
CLL-3A | VH3 | V3-21 | 93.3 | 11 | 1.2 | 9 | 2 | 0.82 | 2-21 | JH4b |
CLL-3B | VH3 | V3-23 | 93.3 | 14 | 2.5 | 6 | 2 | 0.43 | 3-22 | JH4b |
CLL-4A | VH5 | V5-51 | 92.2 | 17 | 2.4 | 6 | 5 | 0.35 | ND | JH5b |
CLL-4B | VH4 | V4-34 | 96.9 | 5 | 4 | 4 | >4 | 0.8 | 5-05 | JH6b |
CLL-5A | VH1 | V1-02 | 90.1 | 21 | 1.33 | 8 | 3 | 0.38 | 2-21 | JH4b |
CLL-5B | VH4 | V4-34 | 94.8 | 13 | 2.25 | 2 | >2 | 0.15 | 2-21 | JH4b |
CLL-6A | VH3 | V3-23 | 90.8 | 22 | 0.83 | 5 | 4 | 0.22 | 6-19 | JH4b |
CLL-6B | VH1 | V1-18 | 93.2 | 16 | 3 | 4 | 1 | 0.25 | ND | JH4b |
CLL-7A | VH3 | V3-13 | 99.0 | 2 | 1 | 1 | >1 | 0.5 | 2-15 | JH4b |
CLL-7B | VH4 | V4-34 | 92.4 | 16 | 0.78 | 6 | 1 | 0.37 | 3-22 | JH4b |
CLL-8A | VH3 | V3-23 | 93.2 | 12 | 0.71 | 8 | >8 | 0.67 | 3-03 | JH4b |
CLL-8B | VH3 | V3-30.3 | 98.3 | 5 | 0.67 | 0 | 0 | 0 | 2-02 | JH4b |
CLL-13A | VH4 | V4-39 | 95.6 | 10 | 4 | 3 | >3 | 0.3 | 6-19 | JH4a |
CLL-13B | VH3 | ND | ND | JH5a | ||||||
CLL-14A | VH4 | ND | 2-02 | JH4a | ||||||
CLL-14B | VH4 | V4-59 | 94.8 | 10 | 1 | 5 | 0.6 | 0.5 | 3-22 | JH1 |
Abbreviations: GC, germline counterpart; FR, framework; RS, replacement/silent mutation ratio; CDR, complementary determining region; CDR/FR, CDR/FR mutation ratio; when all mutations induced replacements, results are expressed as > number of replacements observed; ND, not determined.