Summary of Transcript Levels and Drug Sensitivity Data in Patient Samples
| . | DS . | Non-DS . |
|---|---|---|
| CBS transcript | 0.660 (0.231-3.920) | 0.055 (0.001-0.673) |
| SOD transcript | 2.390 (1.328-12.044) | 0.634 (0.068-7.995) |
| CBR transcript | 0.567 (0.067-3.562) | 0.520 (0.016-9.100) |
| RFC transcript | 0.185 (0.042-0.246) | 0.139 (0.045-0.300) |
| dCK transcript | 2.477 (1.132-9.020) | 0.943 (0.059-11.283) |
| ara-C IC50 (nmol/L) | 100.5 (27.1-370.4) | 420.8 (47.2-3930.7) |
| Daunorubicin IC50 (nmol/L) | 6.75 (1.8-76.3) | 107.4 (4.0-885.0) |
| 3H-ara-CTP (pmol/mg prot) | 735.0 (416.0-1332.6) | 141.1 (18.4-480.0) |
| . | DS . | Non-DS . |
|---|---|---|
| CBS transcript | 0.660 (0.231-3.920) | 0.055 (0.001-0.673) |
| SOD transcript | 2.390 (1.328-12.044) | 0.634 (0.068-7.995) |
| CBR transcript | 0.567 (0.067-3.562) | 0.520 (0.016-9.100) |
| RFC transcript | 0.185 (0.042-0.246) | 0.139 (0.045-0.300) |
| dCK transcript | 2.477 (1.132-9.020) | 0.943 (0.059-11.283) |
| ara-C IC50 (nmol/L) | 100.5 (27.1-370.4) | 420.8 (47.2-3930.7) |
| Daunorubicin IC50 (nmol/L) | 6.75 (1.8-76.3) | 107.4 (4.0-885.0) |
| 3H-ara-CTP (pmol/mg prot) | 735.0 (416.0-1332.6) | 141.1 (18.4-480.0) |
Transcript levels determined by RT-PCR are normalized to 18S RNA transcripts. The in vitro sensitivity data were determined by the MTT assay and 3H-ara-CTP data were determined after in vitro incubations with 3H-ara-C. The values listed are median, with the range of values listed in parentheses.