Table 1.

Therapy Courses

Drug Dose Day
1 2 3 4 5
Prephase V* Prednisone (orally/IV)  30 mg/m2 x  x  x  x  x 
 Cyclophosphamide (IV 1 h)  200 mg/m2 x  x x  x  x 
 Methotrexate‡ IT 12 mg x 
 Cytarabine‡ IT 30 mg x 
 Prednisolone‡ IT 10 mg x  
 
Course A Dexamethasone (orally/IV)  10 mg/m2 x  x x  x  x  
 Ifosfamide (IV 1 h)  800 mg/m2 x  x  x  x  x  
 Methotrexate IV 24 h† 500 mg/m2 x  
 Methotrexate‡ IT  12 mg  x 
 Cytarabine‡ IT  30 mg  x  
 Prednisolone‡ IT 10 mg  x  
 Cytarabine IV 1 h  150 mg/m2    x − x1-153 x − x1-153 
 Etoposide IV 1 h 100 mg/m2    x  x  
 
Course B Dexamethasone (orally/IV)  10 mg/m2 x  x x  x  x  
 Cyclophosphamide (IV 1 h)  200 mg/m2 x  x  x  x  x  
 Methotrexate IV 24 h† 500 mg/m2 x  
 Methotrexate‡ IT 12 mg  x  
 Cytarabine‡ IT  30 mg  x 
 Prednisolone‡ IT  10 mg  x  
 Doxorubicin IV 1 h 25 mg/m2    x  x  
 
Course AA1-155 Dexamethasone (orally/IV)  10 mg/m2 x  x x  x  x  
 Ifosfamide (IV 1 h)  800 mg/m2 x  x  x  x  x  
 Methotrexate IV 24 h1-154 5 g/m2 x  
 Methotrexate‡ IT  6 mg  x    x  
 Cytarabine‡ IT  15 mg  x    x  
 Prednisolone‡ IT  5 mg  x    x  
 Vincristine IV  1.5 mg/m2 # x  
 Cytarabine IV 1 h  150 mg/m2    x − x1-153 x − x1-153 
 Etoposide IV 1 h 100 mg/m2    x  x  
 
Course BB1-155 Dexamethasone (orally/IV)  10 mg/m2 x  x x  x  x  
 Cyclophosphamide (IV 1 h)  200 mg/m2 x  x  x  x  x  
 Methotrexate IV 24 h1-154 5 g/m2 x  
 Methotrexate‡ IT 6 mg  x     x  
 Cytarabine‡ IT  15 mg x     x  
 Prednisolone‡ IT  5 mg  x    x  
 Vincristine IV  1.5 mg/m2 # x  
 Doxorubicin IV 1 h  25 mg/m2    x  x  
 
Course CC1-155 Dexamethasone (orally/IV)  20 mg/m2 x  x  x  x  x 
 Vindesine IV  3 mg/m2 1-160 x 
 Cytarabine (IV 3 h)  2 g/m2 x − x1-153 x − x1-153  
 Etoposide IV 1 h  150 mg/m2   x  x  x  
 Methotrexate‡ IT  12 mg     x  
 Cytarabine‡ IT  30 mg     x  
 Prednisolone‡ IT  10 mg     x 
Drug Dose Day
1 2 3 4 5
Prephase V* Prednisone (orally/IV)  30 mg/m2 x  x  x  x  x 
 Cyclophosphamide (IV 1 h)  200 mg/m2 x  x x  x  x 
 Methotrexate‡ IT 12 mg x 
 Cytarabine‡ IT 30 mg x 
 Prednisolone‡ IT 10 mg x  
 
Course A Dexamethasone (orally/IV)  10 mg/m2 x  x x  x  x  
 Ifosfamide (IV 1 h)  800 mg/m2 x  x  x  x  x  
 Methotrexate IV 24 h† 500 mg/m2 x  
 Methotrexate‡ IT  12 mg  x 
 Cytarabine‡ IT  30 mg  x  
 Prednisolone‡ IT 10 mg  x  
 Cytarabine IV 1 h  150 mg/m2    x − x1-153 x − x1-153 
 Etoposide IV 1 h 100 mg/m2    x  x  
 
Course B Dexamethasone (orally/IV)  10 mg/m2 x  x x  x  x  
 Cyclophosphamide (IV 1 h)  200 mg/m2 x  x  x  x  x  
 Methotrexate IV 24 h† 500 mg/m2 x  
 Methotrexate‡ IT 12 mg  x  
 Cytarabine‡ IT  30 mg  x 
 Prednisolone‡ IT  10 mg  x  
 Doxorubicin IV 1 h 25 mg/m2    x  x  
 
Course AA1-155 Dexamethasone (orally/IV)  10 mg/m2 x  x x  x  x  
 Ifosfamide (IV 1 h)  800 mg/m2 x  x  x  x  x  
 Methotrexate IV 24 h1-154 5 g/m2 x  
 Methotrexate‡ IT  6 mg  x    x  
 Cytarabine‡ IT  15 mg  x    x  
 Prednisolone‡ IT  5 mg  x    x  
 Vincristine IV  1.5 mg/m2 # x  
 Cytarabine IV 1 h  150 mg/m2    x − x1-153 x − x1-153 
 Etoposide IV 1 h 100 mg/m2    x  x  
 
Course BB1-155 Dexamethasone (orally/IV)  10 mg/m2 x  x x  x  x  
 Cyclophosphamide (IV 1 h)  200 mg/m2 x  x  x  x  x  
 Methotrexate IV 24 h1-154 5 g/m2 x  
 Methotrexate‡ IT 6 mg  x     x  
 Cytarabine‡ IT  15 mg x     x  
 Prednisolone‡ IT  5 mg  x    x  
 Vincristine IV  1.5 mg/m2 # x  
 Doxorubicin IV 1 h  25 mg/m2    x  x  
 
Course CC1-155 Dexamethasone (orally/IV)  20 mg/m2 x  x  x  x  x 
 Vindesine IV  3 mg/m2 1-160 x 
 Cytarabine (IV 3 h)  2 g/m2 x − x1-153 x − x1-153  
 Etoposide IV 1 h  150 mg/m2   x  x  x  
 Methotrexate‡ IT  12 mg     x  
 Cytarabine‡ IT  30 mg     x  
 Prednisolone‡ IT  10 mg     x 
*

Amendment July 1993: cyclophosphamide day 1, 2 only, dexamethasone instead of prednisone, see text.

†

Ten percent of dose within 0.5 hours, 90% of dose IV over 23.5 hours, leucovorin rescue at 12 mg/m2 IV at 48 and 54 hours.

‡

Doses were adjusted for children less than 3 years of age. In courses A, B, AA, and BB, IT therapy was administered 2 hours after the beginning of MTX IV infusion.

F1-153

Twelve hours apart.

F1-155

For CNS-pos. patients, chemotherapy was applied intraventricularly as described in the chemotherapy section.

F1-154

Ten percent of dose within 0.5 hours, 90% IV over 23.5 hours, leucovorin rescue (racemic folinic acid) IV at 30 mg/m2 at 42 hours and 15 mg/m2 at 48 and 54 hours. See text for adjustment of leucovorin dose in case of impaired MTX excretion.

#Maximum dose, 2 mg.

F1-160

Maximum dose, 5 mg.

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