Incidence of Acute Toxicity5-150 (N = 76)
| Type . | Grade . | ||
|---|---|---|---|
| 1, 2 . | 3 . | 4 . | |
| Leukopenia | — | 2 | 74 |
| Thrombocytopenia | 18 | 18 | 37 |
| Anemia | 17 | 36 | 16 |
| Hemorrhage | 11 | 1 | — |
| Infection | 35 | 9 | 7 |
| Fever (no infection) | 47 | 3 | — |
| GU | 21 | 1 | — |
| Nausea | 45 | 5 | — |
| Vomiting | 40 | 2 | — |
| Diarrhea | 35 | 1 | — |
| Stomatitis | 37 | 9 | — |
| Liver | 46 | 4 | 3 |
| Pulmonary | 25 | 4 | 1 |
| Cardiac | 15 | 2 | — |
| Hypertension | 4 | — | — |
| Hypotension | 12 | 2 | — |
| Skin | 25 | 1 | — |
| Allergy | 6 | 2 | 1 |
| Phlebitis | 6 | 3 | — |
| Local (no phlebitis) | 5 | — | — |
| Alopecia | 57 | — | — |
| Weight gain | 10 | 2 | — |
| Weight loss | 30 | 1 | — |
| Neurosensory | 33 | 1 | — |
| Neuromotor | 33 | 3 | 1 |
| Neuropsych | 14 | 2 | — |
| Neuroclinical | 27 | 5 | 1 |
| Metabolic | 38 | 4 | — |
| Coagulation | 2 | — | — |
| Worst degree (nonhematologic) | 9 | 40 | 27 |
| Type . | Grade . | ||
|---|---|---|---|
| 1, 2 . | 3 . | 4 . | |
| Leukopenia | — | 2 | 74 |
| Thrombocytopenia | 18 | 18 | 37 |
| Anemia | 17 | 36 | 16 |
| Hemorrhage | 11 | 1 | — |
| Infection | 35 | 9 | 7 |
| Fever (no infection) | 47 | 3 | — |
| GU | 21 | 1 | — |
| Nausea | 45 | 5 | — |
| Vomiting | 40 | 2 | — |
| Diarrhea | 35 | 1 | — |
| Stomatitis | 37 | 9 | — |
| Liver | 46 | 4 | 3 |
| Pulmonary | 25 | 4 | 1 |
| Cardiac | 15 | 2 | — |
| Hypertension | 4 | — | — |
| Hypotension | 12 | 2 | — |
| Skin | 25 | 1 | — |
| Allergy | 6 | 2 | 1 |
| Phlebitis | 6 | 3 | — |
| Local (no phlebitis) | 5 | — | — |
| Alopecia | 57 | — | — |
| Weight gain | 10 | 2 | — |
| Weight loss | 30 | 1 | — |
| Neurosensory | 33 | 1 | — |
| Neuromotor | 33 | 3 | 1 |
| Neuropsych | 14 | 2 | — |
| Neuroclinical | 27 | 5 | 1 |
| Metabolic | 38 | 4 | — |
| Coagulation | 2 | — | — |
| Worst degree (nonhematologic) | 9 | 40 | 27 |
There was 1 grade-4 pulmonary embolus, 1 grade-4 pancreatitis, and 63 grade-4 granulocytopenia.