Correlation of FAB Subtype, MDR1 Expression, and Functional Efflux With Complete Remission Rate Among 352 Untreated AML Patients
. | All Patients . | MDR1 (MRK16) Expression . | Efflux (DiOC2) . | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Positive (D ≥ 0.20) . | Negative/Dim (D < 0.20) . | Positive (D ≥ 0.20) . | Negative (D < 0.20) . | |||||||
FAB | Patients | % CR | Patients | % CR | Patients | % CR | Patients | % CR | Patients | % CR |
M1 | 72 | 38 | 29 | 31 | 43 | 42 | 37 | 24 | 30 | 47 |
M2 | 145 | 63 | 52 | 56 | 93 | 68 | 73 | 58 | 59 | 69 |
M3 | 30 | 40 | 2 | 100 | 28 | 36 | 1 | 0 | 24 | 46 |
M4 | 54 | 59 | 8 | 50 | 46 | 61 | 17 | 71 | 29 | 52 |
M5 | 31 | 48 | 1 | 100 | 30 | 47 | 4 | 75 | 23 | 43 |
Other | 20 | 35 | 7 | 29 | 12 | 42 | 10 | 30 | 7 | 43 |
Total | 352 | 53 | 99 | 47 | 252 | 55 | 142 | 49 | 172 | 55 |
. | All Patients . | MDR1 (MRK16) Expression . | Efflux (DiOC2) . | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Positive (D ≥ 0.20) . | Negative/Dim (D < 0.20) . | Positive (D ≥ 0.20) . | Negative (D < 0.20) . | |||||||
FAB | Patients | % CR | Patients | % CR | Patients | % CR | Patients | % CR | Patients | % CR |
M1 | 72 | 38 | 29 | 31 | 43 | 42 | 37 | 24 | 30 | 47 |
M2 | 145 | 63 | 52 | 56 | 93 | 68 | 73 | 58 | 59 | 69 |
M3 | 30 | 40 | 2 | 100 | 28 | 36 | 1 | 0 | 24 | 46 |
M4 | 54 | 59 | 8 | 50 | 46 | 61 | 17 | 71 | 29 | 52 |
M5 | 31 | 48 | 1 | 100 | 30 | 47 | 4 | 75 | 23 | 43 |
Other | 20 | 35 | 7 | 29 | 12 | 42 | 10 | 30 | 7 | 43 |
Total | 352 | 53 | 99 | 47 | 252 | 55 | 142 | 49 | 172 | 55 |