Changes in the Platelet Mobility Index Around the Transitional Time Point From 1,500 s−1 to 4,500 s−1 During Blood Perfusion of a BSS, vWD Type 3, and Af Patient*
. | Shear Rate: . | 1,500 s−1 . | → . | 4,500 s−1 . |
---|---|---|---|---|
BSS-1 | 11.2 ± 2.2 | → | 9.8 ± 1.9 | |
vWD type 3 | 10.6 ± 1.6 | → | 9.6 ± 1.4 | |
Af-1 | 9 ± 2.5 | → | ||
Control | 12 ± 1.6 | → | 9 ± 2.4 |
. | Shear Rate: . | 1,500 s−1 . | → . | 4,500 s−1 . |
---|---|---|---|---|
BSS-1 | 11.2 ± 2.2 | → | 9.8 ± 1.9 | |
vWD type 3 | 10.6 ± 1.6 | → | 9.6 ± 1.4 | |
Af-1 | 9 ± 2.5 | → | ||
Control | 12 ± 1.6 | → | 9 ± 2.4 |
Data are from the experiments described in the legends to Fig 5(BSS and type 3 vWD) and Fig 6 (Af) and obtained at 10 seconds before (1,500 s−1) and after (4,500 s−1) the shear rate transition. Each platelet mobility index (during 2 seconds; Materials and Methods) represents the mean ± SD of five index values derived from five nonoverlapping areas (110 × 73 μm) in a single frame. Note that the platelet mobility index of Af (underlined) greatly increased after the shear rate elevation, suggesting the breakdown of platelet immobilization to the surface once established.