ED50 Concentrations for Drug-Induced Apoptosis
| Cell Type . | ED50 Concentration ± SD . | ||
|---|---|---|---|
| Epirubicin (ng/mL) . | Etoposide (ng/mL) . | Paclitaxel (ng/mL) . | |
| H9 3D8 mock | 51.3 ± 2.3 | 710.8 ± 37.4 | 7.4 ± 1.2 |
| nbk clone no. 2 | 4.39 ± 0.92 | 52.1 ± 5.5 | 0.73 ± 0.9 |
| (11.7) | (13.6) | (10.1) | |
| nbk clone no. 10 | 4.1 ± 1.3 | 18.1 ± 2.3 | 0.35 ± 0.8 |
| (12.5) | (39.3) | (21.14) | |
| nbk clone no. 16 | 4.2 ± 0.3 | 38.9 ± 7.3 | 0.41 ± 0.8 |
| (12.2) | (18.3) | (18) | |
| Cell Type . | ED50 Concentration ± SD . | ||
|---|---|---|---|
| Epirubicin (ng/mL) . | Etoposide (ng/mL) . | Paclitaxel (ng/mL) . | |
| H9 3D8 mock | 51.3 ± 2.3 | 710.8 ± 37.4 | 7.4 ± 1.2 |
| nbk clone no. 2 | 4.39 ± 0.92 | 52.1 ± 5.5 | 0.73 ± 0.9 |
| (11.7) | (13.6) | (10.1) | |
| nbk clone no. 10 | 4.1 ± 1.3 | 18.1 ± 2.3 | 0.35 ± 0.8 |
| (12.5) | (39.3) | (21.14) | |
| nbk clone no. 16 | 4.2 ± 0.3 | 38.9 ± 7.3 | 0.41 ± 0.8 |
| (12.2) | (18.3) | (18) | |
Cells were exposed to cytostatic drugs for 72 hours. Apoptosis was determined on the single cell level by measuring the DNA content of individual nuclei by flow cytometry. Numbers in brackets indicate the factor of sensitization as compared with the control cells. Data represent the mean of triplicates ± SD.