Table 2.

Human Progenitors in the BM of NOD/SCID Mice Transplanted With CD34+CD38−/low Cells That Were Cultured Ex Vivo for 6 Days

Cytokine Combination Total Colonies*Primitive Colonies
SCF + FL  5 ± 1  0 ± 0 
SCF + FL + IL6RIL6 chimera  80 ± 10 11 ± 4 
Cytokine Combination Total Colonies*Primitive Colonies
SCF + FL  5 ± 1  0 ± 0 
SCF + FL + IL6RIL6 chimera  80 ± 10 11 ± 4 
*

Data shown represent mean ± SE from 3 independent experiments (P = .01, 2 tails, paired t-test).

With SCF + FL, only macrophage colonies were found. When IL6RIL6 was added, mixed GEMM, BFU-E, and blast colonies were seen.

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