Table 3. Amino Acid Conservation Between... | American Society of Hematology

Table 3.

Amino Acid Conservation Between the EPCR and the 1 and 2 Domains of the CD1 and MHC Class I Proteins

		hCD1d^3-150			mCD1.1^3-151			hHLA-A2^3-152
		α1	α2	α1 + 2	α1	α2	α1 + 2	α1	α2	α1 + 2
hEPCR^3-153	α1	24%			17%			18%
	α2		29%			26%			16%
	α1 + 2			27%			22%			17%
hCD1d	α1	—			58%			11%
	α2		—			59%			23%
	α1 + 2			—			59%			17%
mCD1.1	α1	—			—			15%
	α2		—			—			17%
	α1 + 2			—			—			16%

		hCD1d^3-150			mCD1.1^3-151			hHLA-A2^3-152
		α1	α2	α1 + 2	α1	α2	α1 + 2	α1	α2	α1 + 2
hEPCR^3-153	α1	24%			17%			18%
	α2		29%			26%			16%
	α1 + 2			27%			22%			17%
hCD1d	α1	—			58%			11%
	α2		—			59%			23%
	α1 + 2			—			59%			17%
mCD1.1	α1	—			—			15%
	α2		—			—			17%
	α1 + 2			—			—			16%

All α1 and α2 domains were defined by the exon structure of the respective genes. Each pair of amino acid sequences was optimally aligned using clustalW software.34 The number of conserved (identical) residues was then counted and is expressed as a percentage of the total compared regions (including gaps introduced for optimal alignment).

F3-150

Human CD1d, exons 2 and 3.36

F3-151

Murine CD1.1, exons 2 and 3.47

F3-152

Human HLA-A2, exons 2 and 3.37

F3-153

Human EPCR, exons II and III (this report).

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