Binding Characteristics of FRAs and Number of GP IIb/IIIa Receptors Per Platelet on Chimpanzee A-264, Control Chimpanzee, and Human Platelets
| Species . | Kd (nmol/L) . | koff (×104/s−1) (A1-L) . | No. of Receptors Per Platelet (×10−3) . | ||
|---|---|---|---|---|---|
| C . | A1-L . | A2-L . | |||
| Chimpanzee A-264 | 16 ± 3 | 0.30 ± 0.11 | 0.08 ± 0.03 | 5.2 ± 0.4 | 78 ± 14 |
| Control chimpanzee | 15 ± 3 | 0.28 ± 0.12 | 0.09 ± 0.04 | 5.1 ± 0.3 | 72 ± 12 |
| Human platelets | 15 ± 6 | 0.33 ± 14 | 0.10 ± 0.05 | 4.6 ± 0.4 | 57 ± 12* |
| Species . | Kd (nmol/L) . | koff (×104/s−1) (A1-L) . | No. of Receptors Per Platelet (×10−3) . | ||
|---|---|---|---|---|---|
| C . | A1-L . | A2-L . | |||
| Chimpanzee A-264 | 16 ± 3 | 0.30 ± 0.11 | 0.08 ± 0.03 | 5.2 ± 0.4 | 78 ± 14 |
| Control chimpanzee | 15 ± 3 | 0.28 ± 0.12 | 0.09 ± 0.04 | 5.1 ± 0.3 | 72 ± 12 |
| Human platelets | 15 ± 6 | 0.33 ± 14 | 0.10 ± 0.05 | 4.6 ± 0.4 | 57 ± 12* |
The values of kd and koff were determined as described in Bednar et al.32 Mean ± SD of at least three measurements.
Average of measurements in 100 human subjects.