Allele Frequencies (%) and Homozygosity Rates (%) for HLA-Bw4/6 and HSP183/188 Alleles
| . | Newborns n = 325 . | Males n = 150 . | Females n = 175 . | Patients n = 114 . | Males n = 61 . | Females n = 53 . |
|---|---|---|---|---|---|---|
| Bw4 | ||||||
| AF | 56.6 | 54.7 | 46.9 | 59.6 | 63.9 | 54.7 |
| HR | 10.8 | 9.3 | 12.0 | 9.6 | 13.1 | 5.7 |
| Bw6 | ||||||
| AF | 89.5 | 90.7 | 88.6 | 90.4 | 86.9 | 94.3 |
| HR | 43.7 | 45.3 | 42.3 | 40.4 | 36.1 | 45.3 |
| HSP-188 | ||||||
| AF | 59.4 | 59.3 | 59.4 | 50.0 | 49.2 | 50.9 |
| HR | 15.7 | 19.33-150 | 12.6 | 8.8 | 6.6 | 11.3 |
| HSP-183 | ||||||
| AF | 84.0 | 80.0 | 87.4 | 91.2 | 93.43-151 | 88.7 |
| HR | 40.3 | 40.6 | 40.6 | 50.0 | 50.8 | 49.1 |
| . | Newborns n = 325 . | Males n = 150 . | Females n = 175 . | Patients n = 114 . | Males n = 61 . | Females n = 53 . |
|---|---|---|---|---|---|---|
| Bw4 | ||||||
| AF | 56.6 | 54.7 | 46.9 | 59.6 | 63.9 | 54.7 |
| HR | 10.8 | 9.3 | 12.0 | 9.6 | 13.1 | 5.7 |
| Bw6 | ||||||
| AF | 89.5 | 90.7 | 88.6 | 90.4 | 86.9 | 94.3 |
| HR | 43.7 | 45.3 | 42.3 | 40.4 | 36.1 | 45.3 |
| HSP-188 | ||||||
| AF | 59.4 | 59.3 | 59.4 | 50.0 | 49.2 | 50.9 |
| HR | 15.7 | 19.33-150 | 12.6 | 8.8 | 6.6 | 11.3 |
| HSP-183 | ||||||
| AF | 84.0 | 80.0 | 87.4 | 91.2 | 93.43-151 | 88.7 |
| HR | 40.3 | 40.6 | 40.6 | 50.0 | 50.8 | 49.1 |
Abbreviations: AF, allele frequency; HR, homozygosity rate.
Higher than the homozygosity rate in male patients (P = .02).
Higher than the allele frequency in male-newborns (P = .03). None of the homozygosity rates in newborns was significantly different from the expected homozygosity rates (11.4% for Bw4, 44.0% for Bw6, 14.3% for HSP-188, and 38.7% for HSP-183).