Allele Frequencies and Homozygosity Rates (%) in the HLA-DRB1 Locus
| . | Newborns n = 325 . | Males n = 150 . | Females n = 175 . | Patients n = 114 . | Males n = 61 . | Females n = 53 . |
|---|---|---|---|---|---|---|
| DR1 | ||||||
| AF | 20.6 | 19.3 | 21.7 | 12.0 | 11.5 | 26.4 |
| HR | 0.3 | 0.0 | 0.6 | 1.8 | 0.0 | 3.8 |
| DR2* | ||||||
| AF | 30.5 | 15.7 | 27.4 | 36.0 | 29.5 | 43.4 |
| HR | 4.3 | 6.0 | 2.9 | 2.6 | 3.3 | 1.9 |
| DR3† | ||||||
| AF | 28.3 | 28.7 | 28.0 | 23.7 | 24.6 | 24.5 |
| HR | 3.4 | 2.0 | 4.6 | 0.9 | 0.0 | 1.9 |
| DR4 | ||||||
| AF | 29.5 | 27.3 | 31.4 | 41.2 | 52.5 | 28.3 |
| HR | 1.5 | 1.3 | 1.7 | 7.9 | 11.5 | 3.8 |
| DR5*,‡ | ||||||
| AF | 16.0 | 19.3 | 13.1 | 11.4 | 9.8 | 13.3 |
| HR | 4.6 | 4.7 | 4.6 | 4.4 | 3.3 | 5.7 |
| DR6*,‡ | ||||||
| AF | 27.4 | 29.3 | 25.7 | 17.5 | 16.4 | 18.9 |
| HR | 4.0 | 2.7 | 5.1 | 3.5 | 4.9 | 1.9 |
| DR7 | ||||||
| AF | 26.8 | 23.3 | 29.7 | 25.4 | 29.5 | 20.8 |
| HR | 1.2 | 0.0 | 2.3 | 1.8 | 3.3 | 0.0 |
| DR8 | ||||||
| AF | 3.4 | 2.7 | 4.0 | 6.1 | 3.3 | 9.4 |
| DR9 | ||||||
| AF | 2.8 | 3.3 | 2.3 | 2.6 | 3.3 | 1.9 |
| DR10 | ||||||
| AF | 2.5 | 2.6 | 2.3 | 1.8 | 1.6 | 1.9 |
| . | Newborns n = 325 . | Males n = 150 . | Females n = 175 . | Patients n = 114 . | Males n = 61 . | Females n = 53 . |
|---|---|---|---|---|---|---|
| DR1 | ||||||
| AF | 20.6 | 19.3 | 21.7 | 12.0 | 11.5 | 26.4 |
| HR | 0.3 | 0.0 | 0.6 | 1.8 | 0.0 | 3.8 |
| DR2* | ||||||
| AF | 30.5 | 15.7 | 27.4 | 36.0 | 29.5 | 43.4 |
| HR | 4.3 | 6.0 | 2.9 | 2.6 | 3.3 | 1.9 |
| DR3† | ||||||
| AF | 28.3 | 28.7 | 28.0 | 23.7 | 24.6 | 24.5 |
| HR | 3.4 | 2.0 | 4.6 | 0.9 | 0.0 | 1.9 |
| DR4 | ||||||
| AF | 29.5 | 27.3 | 31.4 | 41.2 | 52.5 | 28.3 |
| HR | 1.5 | 1.3 | 1.7 | 7.9 | 11.5 | 3.8 |
| DR5*,‡ | ||||||
| AF | 16.0 | 19.3 | 13.1 | 11.4 | 9.8 | 13.3 |
| HR | 4.6 | 4.7 | 4.6 | 4.4 | 3.3 | 5.7 |
| DR6*,‡ | ||||||
| AF | 27.4 | 29.3 | 25.7 | 17.5 | 16.4 | 18.9 |
| HR | 4.0 | 2.7 | 5.1 | 3.5 | 4.9 | 1.9 |
| DR7 | ||||||
| AF | 26.8 | 23.3 | 29.7 | 25.4 | 29.5 | 20.8 |
| HR | 1.2 | 0.0 | 2.3 | 1.8 | 3.3 | 0.0 |
| DR8 | ||||||
| AF | 3.4 | 2.7 | 4.0 | 6.1 | 3.3 | 9.4 |
| DR9 | ||||||
| AF | 2.8 | 3.3 | 2.3 | 2.6 | 3.3 | 1.9 |
| DR10 | ||||||
| AF | 2.5 | 2.6 | 2.3 | 1.8 | 1.6 | 1.9 |
Homozygosity rates were not shown when there was no more than one homozygotes in any group.
Abbreviations: AF, allele frequency; HR, homozygosity rate.
Because of low frequencies of DRB1*12, 14 and 16, the alleles of the classical DR types DR2, DR5 and DR6 were grouped together.
12 in the DR5 group, and DRB1*13,
14 in the DR6 group did not show any significant change separately. For P values, see text.
The typing system used cannot distinguish between DRB1*17 and DRB1*18.
DRB1*11,